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CHECK report for affyPLM on tokay1

This page was generated on 2020-09-19 10:18:39 -0400 (Sat, 19 Sep 2020).

TO THE DEVELOPERS/MAINTAINERS OF THE affyPLM PACKAGE: Please make sure to use the following settings in order to reproduce any error or warning you see on this page.
Package 33/1912HostnameOS / ArchINSTALLBUILDCHECKBUILD BIN
affyPLM 1.65.0
Ben Bolstad
Snapshot Date: 2020-09-18 14:43:25 -0400 (Fri, 18 Sep 2020)
URL: https://git.bioconductor.org/packages/affyPLM
Branch: master
Last Commit: 6b1f227
Last Changed Date: 2020-04-27 14:08:49 -0400 (Mon, 27 Apr 2020)
malbec1 Linux (Ubuntu 18.04.4 LTS) / x86_64  OK  OK  OK UNNEEDED, same version exists in internal repository
nebbiolo1 Linux (Ubuntu 20.04.1 LTS) / x86_64  OK  OK  WARNINGS 
tokay1 Windows Server 2012 R2 Standard / x64  OK  OK [ OK ] OK UNNEEDED, same version exists in internal repository
riesling1 Windows Server 2019 Standard / x64  OK  OK  OK  OK 
merida1 macOS 10.14.6 Mojave / x86_64  OK  OK  OK  OK UNNEEDED, same version exists in internal repository

Summary

Package: affyPLM
Version: 1.65.0
Command: C:\Users\biocbuild\bbs-3.12-bioc\R\bin\R.exe CMD check --force-multiarch --install=check:affyPLM.install-out.txt --library=C:\Users\biocbuild\bbs-3.12-bioc\R\library --no-vignettes --timings affyPLM_1.65.0.tar.gz
StartedAt: 2020-09-19 00:04:13 -0400 (Sat, 19 Sep 2020)
EndedAt: 2020-09-19 00:10:35 -0400 (Sat, 19 Sep 2020)
EllapsedTime: 382.4 seconds
RetCode: 0
Status:  OK  
CheckDir: affyPLM.Rcheck
Warnings: 0

Command output

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###
### Running command:
###
###   C:\Users\biocbuild\bbs-3.12-bioc\R\bin\R.exe CMD check --force-multiarch --install=check:affyPLM.install-out.txt --library=C:\Users\biocbuild\bbs-3.12-bioc\R\library --no-vignettes --timings affyPLM_1.65.0.tar.gz
###
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* using log directory 'C:/Users/biocbuild/bbs-3.12-bioc/meat/affyPLM.Rcheck'
* using R version 4.0.2 (2020-06-22)
* using platform: x86_64-w64-mingw32 (64-bit)
* using session charset: ISO8859-1
* using option '--no-vignettes'
* checking for file 'affyPLM/DESCRIPTION' ... OK
* this is package 'affyPLM' version '1.65.0'
* checking package namespace information ... OK
* checking package dependencies ... OK
* checking if this is a source package ... OK
* checking if there is a namespace ... OK
* checking for hidden files and directories ... OK
* checking for portable file names ... OK
* checking whether package 'affyPLM' can be installed ... OK
* checking installed package size ... OK
* checking package directory ... OK
* checking 'build' directory ... OK
* checking DESCRIPTION meta-information ... OK
* checking top-level files ... OK
* checking for left-over files ... OK
* checking index information ... OK
* checking package subdirectories ... OK
* checking R files for non-ASCII characters ... OK
* checking R files for syntax errors ... OK
* loading checks for arch 'i386'
** checking whether the package can be loaded ... OK
** checking whether the package can be loaded with stated dependencies ... OK
** checking whether the package can be unloaded cleanly ... OK
** checking whether the namespace can be loaded with stated dependencies ... OK
** checking whether the namespace can be unloaded cleanly ... OK
* loading checks for arch 'x64'
** checking whether the package can be loaded ... OK
** checking whether the package can be loaded with stated dependencies ... OK
** checking whether the package can be unloaded cleanly ... OK
** checking whether the namespace can be loaded with stated dependencies ... OK
** checking whether the namespace can be unloaded cleanly ... OK
* checking dependencies in R code ... OK
* checking S3 generic/method consistency ... OK
* checking replacement functions ... OK
* checking foreign function calls ... OK
* checking R code for possible problems ... OK
* checking Rd files ... OK
* checking Rd metadata ... OK
* checking Rd cross-references ... OK
* checking for missing documentation entries ... OK
* checking for code/documentation mismatches ... OK
* checking Rd \usage sections ... OK
* checking Rd contents ... OK
* checking for unstated dependencies in examples ... OK
* checking line endings in C/C++/Fortran sources/headers ... OK
* checking line endings in Makefiles ... OK
* checking compilation flags in Makevars ... OK
* checking for GNU extensions in Makefiles ... OK
* checking for portable use of $(BLAS_LIBS) and $(LAPACK_LIBS) ... OK
* checking use of PKG_*FLAGS in Makefiles ... OK
* checking compiled code ... NOTE
Note: information on .o files for i386 is not available
Note: information on .o files for x64 is not available
File 'C:/Users/biocbuild/bbs-3.12-bioc/R/library/affyPLM/libs/i386/affyPLM.dll':
  Found 'abort', possibly from 'abort' (C), 'runtime' (Fortran)
File 'C:/Users/biocbuild/bbs-3.12-bioc/R/library/affyPLM/libs/x64/affyPLM.dll':
  Found 'abort', possibly from 'abort' (C), 'runtime' (Fortran)

Compiled code should not call entry points which might terminate R nor
write to stdout/stderr instead of to the console, nor use Fortran I/O
nor system RNGs. The detected symbols are linked into the code but
might come from libraries and not actually be called.

See 'Writing portable packages' in the 'Writing R Extensions' manual.
* checking files in 'vignettes' ... OK
* checking examples ...
** running examples for arch 'i386' ... OK
Examples with CPU (user + system) or elapsed time > 5s
                user system elapsed
threestep      19.41   0.21   19.61
fitPLM         12.19   0.33   12.52
PLMset2exprSet  5.80   0.11    5.91
** running examples for arch 'x64' ... OK
Examples with CPU (user + system) or elapsed time > 5s
                user system elapsed
threestep      19.31   0.20   19.52
fitPLM         12.22   0.46   12.69
PLMset2exprSet  5.71   0.06    5.77
* checking for unstated dependencies in 'tests' ... OK
* checking tests ...
** running tests for arch 'i386' ...
  Running 'C_code_tests.R'
  Running 'PLM_tests.R'
  Running 'preprocess_tests.R'
  Running 'threestepPLM_tests.R'
 OK
** running tests for arch 'x64' ...
  Running 'C_code_tests.R'
  Running 'PLM_tests.R'
  Running 'preprocess_tests.R'
  Running 'threestepPLM_tests.R'
 OK
* checking for unstated dependencies in vignettes ... OK
* checking package vignettes in 'inst/doc' ... OK
* checking running R code from vignettes ... SKIPPED
* checking re-building of vignette outputs ... SKIPPED
* checking PDF version of manual ... OK
* DONE

Status: 1 NOTE
See
  'C:/Users/biocbuild/bbs-3.12-bioc/meat/affyPLM.Rcheck/00check.log'
for details.



Installation output

affyPLM.Rcheck/00install.out

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###
### Running command:
###
###   C:\cygwin\bin\curl.exe -O https://malbec1.bioconductor.org/BBS/3.12/bioc/src/contrib/affyPLM_1.65.0.tar.gz && rm -rf affyPLM.buildbin-libdir && mkdir affyPLM.buildbin-libdir && C:\Users\biocbuild\bbs-3.12-bioc\R\bin\R.exe CMD INSTALL --merge-multiarch --build --library=affyPLM.buildbin-libdir affyPLM_1.65.0.tar.gz && C:\Users\biocbuild\bbs-3.12-bioc\R\bin\R.exe CMD INSTALL affyPLM_1.65.0.zip && rm affyPLM_1.65.0.tar.gz affyPLM_1.65.0.zip
###
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  % Total    % Received % Xferd  Average Speed   Time    Time     Time  Current
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  0     0    0     0    0     0      0      0 --:--:-- --:--:-- --:--:--     0
100 2395k  100 2395k    0     0  8793k      0 --:--:-- --:--:-- --:--:-- 8938k

install for i386

* installing *source* package 'affyPLM' ...
** using staged installation
** libs
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c LESN.c -o LESN.o
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c PLM_avg_log.c -o PLM_avg_log.o
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c PLM_biweight.c -o PLM_biweight.o
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c PLM_log_avg.c -o PLM_log_avg.o
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c PLM_medianPM.c -o PLM_medianPM.o
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c PLM_median_logPM.c -o PLM_median_logPM.o
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c PLM_medianpolish.c -o PLM_medianpolish.o
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c PLM_modelmatrix.c -o PLM_modelmatrix.o
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c SCAB.c -o SCAB.o
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c chipbackground.c -o chipbackground.o
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c common_types.c -o common_types.o
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c do_PLMrlm.c -o do_PLMrlm.o
do_PLMrlm.c: In function 'do_PLM_rlm':
do_PLMrlm.c:620:7: warning: variable 'first_ind' set but not used [-Wunused-but-set-variable]
   int first_ind;
       ^~~~~~~~~
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c do_PLMrma.c -o do_PLMrma.o
do_PLMrma.c: In function 'do_PLMrma':
do_PLMrma.c:209:7: warning: variable 'first_ind' set but not used [-Wunused-but-set-variable]
   int first_ind;
       ^~~~~~~~~
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c do_PLMthreestep.c -o do_PLMthreestep.o
do_PLMthreestep.c: In function 'do_PLMthreestep':
do_PLMthreestep.c:118:7: warning: variable 'first_ind' set but not used [-Wunused-but-set-variable]
   int first_ind;
       ^~~~~~~~~
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c idealmismatch.c -o idealmismatch.o
idealmismatch.c: In function 'IdealMM_correct_single':
idealmismatch.c:71:7: warning: variable 'first_ind' set but not used [-Wunused-but-set-variable]
   int first_ind;
       ^~~~~~~~~
idealmismatch.c: In function 'SpecificBiweightCorrect_single':
idealmismatch.c:183:7: warning: variable 'first_ind' set but not used [-Wunused-but-set-variable]
   int first_ind;
       ^~~~~~~~~
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c lm_threestep.c -o lm_threestep.o
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c matrix_functions.c -o matrix_functions.o
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c nthLargestPM.c -o nthLargestPM.o
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c preprocess.c -o preprocess.o
preprocess.c: In function 'pp_background':
preprocess.c:158:7: warning: variable 'which_lesn' set but not used [-Wunused-but-set-variable]
   int which_lesn;
       ^~~~~~~~~~
preprocess.c: In function 'pp_bothstages':
preprocess.c:677:12: warning: variable 'cols' set but not used [-Wunused-but-set-variable]
   int rows,cols;
            ^~~~
preprocess.c:677:7: warning: variable 'rows' set but not used [-Wunused-but-set-variable]
   int rows,cols;
       ^~~~
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c psi_fns.c -o psi_fns.o
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c qnorm_probeset.c -o qnorm_probeset.o
qnorm_probeset.c: In function 'qnorm_probeset_c':
qnorm_probeset.c:110:7: warning: variable 'first_ind' set but not used [-Wunused-but-set-variable]
   int first_ind;
       ^~~~~~~~~
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c read_rmaexpress.c -o read_rmaexpress.o
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c rlm_PLM.c -o rlm_PLM.o
rlm_PLM.c: In function 'R_rlm_PLMset_c':
rlm_PLM.c:1481:12: warning: variable 'cols' set but not used [-Wunused-but-set-variable]
   int rows,cols;
            ^~~~
rlm_PLM.c:1481:7: warning: variable 'rows' set but not used [-Wunused-but-set-variable]
   int rows,cols;
       ^~~~
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c rlm_threestep.c -o rlm_threestep.o
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c rmaPLM_pseudo.c -o rmaPLM_pseudo.o
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c rma_PLM.c -o rma_PLM.o
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c rma_common.c -o rma_common.o
rma_common.c: In function 'median':
rma_common.c:60:7: warning: unused variable 'i' [-Wunused-variable]
   int i;
       ^
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c scaling.c -o scaling.o
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c threestep.c -o threestep.o
threestep.c: In function 'threestep_summary':
threestep.c:82:15: warning: variable 'MM' set but not used [-Wunused-but-set-variable]
   double *PM,*MM;
               ^~
threestep.c: In function 'R_threestep_c':
threestep.c:193:12: warning: variable 'cols' set but not used [-Wunused-but-set-variable]
   int rows,cols;
            ^~~~
threestep.c:193:7: warning: variable 'rows' set but not used [-Wunused-but-set-variable]
   int rows,cols;
       ^~~~
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c threestep_PLM.c -o threestep_PLM.o
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c threestep_common.c -o threestep_common.o
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c threestep_summary.c -o threestep_summary.o
threestep_summary.c: In function 'do_3summary':
threestep_summary.c:73:7: warning: variable 'first_ind' set but not used [-Wunused-but-set-variable]
   int first_ind;
       ^~~~~~~~~
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c threestep_summary_methods.c -o threestep_summary_methods.o
"C:/rtools40/mingw32/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c transfns.c -o transfns.o
C:/rtools40/mingw32/bin/gcc -shared -s -static-libgcc -o affyPLM.dll tmp.def LESN.o PLM_avg_log.o PLM_biweight.o PLM_log_avg.o PLM_medianPM.o PLM_median_logPM.o PLM_medianpolish.o PLM_modelmatrix.o SCAB.o chipbackground.o common_types.o do_PLMrlm.o do_PLMrma.o do_PLMthreestep.o idealmismatch.o lm_threestep.o matrix_functions.o nthLargestPM.o preprocess.o psi_fns.o qnorm_probeset.o read_rmaexpress.o rlm_PLM.o rlm_threestep.o rmaPLM_pseudo.o rma_PLM.o rma_common.o scaling.o threestep.o threestep_PLM.o threestep_common.o threestep_summary.o threestep_summary_methods.o transfns.o -LC:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/libs/i386 -lzlib1bioc -lgfortran -lm -lquadmath -LC:/Users/BIOCBU~1/BBS-3~1.12-/R/bin/i386 -lRlapack -LC:/Users/BIOCBU~1/BBS-3~1.12-/R/bin/i386 -lRblas -LC:/extsoft/lib/i386 -LC:/extsoft/lib -LC:/Users/BIOCBU~1/BBS-3~1.12-/R/bin/i386 -lR
installing to C:/Users/biocbuild/bbs-3.12-bioc/meat/affyPLM.buildbin-libdir/00LOCK-affyPLM/00new/affyPLM/libs/i386
** R
** inst
** byte-compile and prepare package for lazy loading
** help
*** installing help indices
  converting help for package 'affyPLM'
    finding HTML links ... done
    MAplot                                  html  
    PLMset-class                            html  
    PLMset2exprSet                          html  
    ReadRMAExpress                          html  
    affyPLM-internal                        html  
    bg.correct.LESN                         html  
    fitPLM                                  html  
    normalize.exprSet                       html  
    normalize.quantiles.probeset            html  
    normalize.scaling                       html  
    preprocess                              html  
    pseudo                                  html  
    rmaPLM                                  html  
    threestep                               html  
    threestepPLM                            html  
** building package indices
** installing vignettes
** testing if installed package can be loaded from temporary location
** testing if installed package can be loaded from final location
** testing if installed package keeps a record of temporary installation path

install for x64

* installing *source* package 'affyPLM' ...
** libs
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c LESN.c -o LESN.o
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c PLM_avg_log.c -o PLM_avg_log.o
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c PLM_biweight.c -o PLM_biweight.o
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c PLM_log_avg.c -o PLM_log_avg.o
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c PLM_medianPM.c -o PLM_medianPM.o
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c PLM_median_logPM.c -o PLM_median_logPM.o
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c PLM_medianpolish.c -o PLM_medianpolish.o
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c PLM_modelmatrix.c -o PLM_modelmatrix.o
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c SCAB.c -o SCAB.o
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c chipbackground.c -o chipbackground.o
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c common_types.c -o common_types.o
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c do_PLMrlm.c -o do_PLMrlm.o
do_PLMrlm.c: In function 'do_PLM_rlm':
do_PLMrlm.c:620:7: warning: variable 'first_ind' set but not used [-Wunused-but-set-variable]
   int first_ind;
       ^~~~~~~~~
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c do_PLMrma.c -o do_PLMrma.o
do_PLMrma.c: In function 'do_PLMrma':
do_PLMrma.c:209:7: warning: variable 'first_ind' set but not used [-Wunused-but-set-variable]
   int first_ind;
       ^~~~~~~~~
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c do_PLMthreestep.c -o do_PLMthreestep.o
do_PLMthreestep.c: In function 'do_PLMthreestep':
do_PLMthreestep.c:118:7: warning: variable 'first_ind' set but not used [-Wunused-but-set-variable]
   int first_ind;
       ^~~~~~~~~
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c idealmismatch.c -o idealmismatch.o
idealmismatch.c: In function 'IdealMM_correct_single':
idealmismatch.c:71:7: warning: variable 'first_ind' set but not used [-Wunused-but-set-variable]
   int first_ind;
       ^~~~~~~~~
idealmismatch.c: In function 'SpecificBiweightCorrect_single':
idealmismatch.c:183:7: warning: variable 'first_ind' set but not used [-Wunused-but-set-variable]
   int first_ind;
       ^~~~~~~~~
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c lm_threestep.c -o lm_threestep.o
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c matrix_functions.c -o matrix_functions.o
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c nthLargestPM.c -o nthLargestPM.o
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c preprocess.c -o preprocess.o
preprocess.c: In function 'pp_background':
preprocess.c:158:7: warning: variable 'which_lesn' set but not used [-Wunused-but-set-variable]
   int which_lesn;
       ^~~~~~~~~~
preprocess.c: In function 'pp_bothstages':
preprocess.c:677:12: warning: variable 'cols' set but not used [-Wunused-but-set-variable]
   int rows,cols;
            ^~~~
preprocess.c:677:7: warning: variable 'rows' set but not used [-Wunused-but-set-variable]
   int rows,cols;
       ^~~~
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c psi_fns.c -o psi_fns.o
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c qnorm_probeset.c -o qnorm_probeset.o
qnorm_probeset.c: In function 'qnorm_probeset_c':
qnorm_probeset.c:110:7: warning: variable 'first_ind' set but not used [-Wunused-but-set-variable]
   int first_ind;
       ^~~~~~~~~
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c read_rmaexpress.c -o read_rmaexpress.o
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c rlm_PLM.c -o rlm_PLM.o
rlm_PLM.c: In function 'R_rlm_PLMset_c':
rlm_PLM.c:1481:12: warning: variable 'cols' set but not used [-Wunused-but-set-variable]
   int rows,cols;
            ^~~~
rlm_PLM.c:1481:7: warning: variable 'rows' set but not used [-Wunused-but-set-variable]
   int rows,cols;
       ^~~~
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c rlm_threestep.c -o rlm_threestep.o
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c rmaPLM_pseudo.c -o rmaPLM_pseudo.o
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c rma_PLM.c -o rma_PLM.o
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c rma_common.c -o rma_common.o
rma_common.c: In function 'median':
rma_common.c:60:7: warning: unused variable 'i' [-Wunused-variable]
   int i;
       ^
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c scaling.c -o scaling.o
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c threestep.c -o threestep.o
threestep.c: In function 'threestep_summary':
threestep.c:82:15: warning: variable 'MM' set but not used [-Wunused-but-set-variable]
   double *PM,*MM;
               ^~
threestep.c: In function 'R_threestep_c':
threestep.c:193:12: warning: variable 'cols' set but not used [-Wunused-but-set-variable]
   int rows,cols;
            ^~~~
threestep.c:193:7: warning: variable 'rows' set but not used [-Wunused-but-set-variable]
   int rows,cols;
       ^~~~
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c threestep_PLM.c -o threestep_PLM.o
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c threestep_common.c -o threestep_common.o
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c threestep_summary.c -o threestep_summary.o
threestep_summary.c: In function 'do_3summary':
threestep_summary.c:73:7: warning: variable 'first_ind' set but not used [-Wunused-but-set-variable]
   int first_ind;
       ^~~~~~~~~
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c threestep_summary_methods.c -o threestep_summary_methods.o
"C:/rtools40/mingw64/bin/"gcc  -I"C:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/include" -I"C:/Users/BIOCBU~1/BBS-3~1.12-/R/include" -DNDEBUG -DHAVE_ZLIB -I'C:/Users/biocbuild/bbs-3.12-bioc/R/library/preprocessCore/include'   -I"C:/extsoft/include"     -O2 -Wall  -std=gnu99 -mfpmath=sse -msse2 -mstackrealign -c transfns.c -o transfns.o
C:/rtools40/mingw64/bin/gcc -shared -s -static-libgcc -o affyPLM.dll tmp.def LESN.o PLM_avg_log.o PLM_biweight.o PLM_log_avg.o PLM_medianPM.o PLM_median_logPM.o PLM_medianpolish.o PLM_modelmatrix.o SCAB.o chipbackground.o common_types.o do_PLMrlm.o do_PLMrma.o do_PLMthreestep.o idealmismatch.o lm_threestep.o matrix_functions.o nthLargestPM.o preprocess.o psi_fns.o qnorm_probeset.o read_rmaexpress.o rlm_PLM.o rlm_threestep.o rmaPLM_pseudo.o rma_PLM.o rma_common.o scaling.o threestep.o threestep_PLM.o threestep_common.o threestep_summary.o threestep_summary_methods.o transfns.o -LC:/Users/biocbuild/bbs-3.12-bioc/R/library/zlibbioc/libs/x64 -lzlib1bioc -lgfortran -lm -lquadmath -LC:/Users/BIOCBU~1/BBS-3~1.12-/R/bin/x64 -lRlapack -LC:/Users/BIOCBU~1/BBS-3~1.12-/R/bin/x64 -lRblas -LC:/extsoft/lib/x64 -LC:/extsoft/lib -LC:/Users/BIOCBU~1/BBS-3~1.12-/R/bin/x64 -lR
installing to C:/Users/biocbuild/bbs-3.12-bioc/meat/affyPLM.buildbin-libdir/affyPLM/libs/x64
** testing if installed package can be loaded
* MD5 sums
packaged installation of 'affyPLM' as affyPLM_1.65.0.zip
* DONE (affyPLM)
* installing to library 'C:/Users/biocbuild/bbs-3.12-bioc/R/library'
package 'affyPLM' successfully unpacked and MD5 sums checked

Tests output

affyPLM.Rcheck/tests_i386/C_code_tests.Rout


R version 4.0.2 (2020-06-22) -- "Taking Off Again"
Copyright (C) 2020 The R Foundation for Statistical Computing
Platform: i386-w64-mingw32/i386 (32-bit)

R is free software and comes with ABSOLUTELY NO WARRANTY.
You are welcome to redistribute it under certain conditions.
Type 'license()' or 'licence()' for distribution details.

R is a collaborative project with many contributors.
Type 'contributors()' for more information and
'citation()' on how to cite R or R packages in publications.

Type 'demo()' for some demos, 'help()' for on-line help, or
'help.start()' for an HTML browser interface to help.
Type 'q()' to quit R.

> ####
> #### This code is messy, possibly incomplete and only for
> #### the use of developers.
> ####
> ####
> 
> test.c.code <-  FALSE
> test.PLM.modelmatrix <- FALSE
> test.rlm <- FALSE
> 
> if (test.c.code){
+   
+   library(affyPLM)
+   narrays <- 10
+   nprobes <- 11
+   nprobetypes <- 2
+   ncols <- 10
+   
+   MMs <- rnorm(narrays*nprobes*nprobetypes)
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   
+                                         #test making intercept column
+   matrix(.C("R_PLM_matrix_intercept",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),0)[[1]],ncol=10)
+   
+                                         #test making an MM covariate column
+   matrix(.C("R_PLM_matrix_MM",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(1),as.double(MMs))[[1]],ncol=10)
+   
+                                         # sample effect aka chip effect, aka expression values
+   matrix(.C("R_PLM_matrix_sample_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0))[[1]],ncol=10)
+   matrix(.C("R_PLM_matrix_sample_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1))[[1]],ncol=10)
+   matrix(.C("R_PLM_matrix_sample_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1))[[1]],ncol=10)
+   
+   
+   
+                                         #probe-type parameter overall
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(0),integer(narrays),as.integer(1))[[1]],ncol=10)
+   
+                                         #probe-type parameter within sample
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(1),integer(narrays),as.integer(1))[[1]],ncol=10)
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(1),integer(narrays),as.integer(1))[[1]],ncol=10)
+   ncols <- 20
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(1),integer(narrays),as.integer(0))[[1]],ncol=20)
+   
+   
+                                         #probe-type-parameter within a chip-level factor (eg treatment, or genotype variable)
+   trt.cov <- rep(0:1,5)
+   ncols <- 10
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(2),as.integer(trt.cov),as.integer(1))[[1]],ncol=10)
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(2),as.integer(trt.cov),as.integer(1))[[1]],ncol=10)
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(2),as.integer(trt.cov),as.integer(1))[[1]],ncol=10)
+   
+   trt.cov <- rep(0:4,2)
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(2),as.integer(trt.cov),as.integer(4))[[1]],ncol=10)
+   
+   
+   
+   
+                                         #probe effects - overall
+   ncols <- 11
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   
+   
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(0),as.integer(trt.cov),as.integer(4))[[1]],ncol=11)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(0),as.integer(trt.cov),as.integer(4))[[1]],ncol=11)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(0),as.integer(trt.cov),as.integer(4))[[1]],ncol=11)
+   
+   
+   
+                                         #probe effects within treatment or genotype factor
+   trt.cov <- rep(0:1,5)
+   ncols <- 22
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(2),as.integer(trt.cov),as.integer(1))[[1]],ncol=22)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(2),as.integer(trt.cov),as.integer(1))[[1]],ncol=22)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(2),as.integer(trt.cov),as.integer(1))[[1]],ncol=22)
+   
+   
+                                         #probe effects within probetype
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(3),as.integer(trt.cov),as.integer(1))[[1]],ncol=22)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(3),as.integer(trt.cov),as.integer(1))[[1]],ncol=22)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(3),as.integer(trt.cov),as.integer(1))[[1]],ncol=22)
+   
+   
+                                         #probe effects within probetype within treatment or genotype factor variable
+   trt.cov <- rep(0:1,5)
+   ncols <- 44
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(4),as.integer(trt.cov),as.integer(1))[[1]],ncol=44)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(4),as.integer(trt.cov),as.integer(1))[[1]],ncol=44)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(4),as.integer(trt.cov),as.integer(1))[[1]],ncol=44)
+   
+   nprobetypes <- 1
+   trt.cov <- rep(0:1,5)
+   ncols <- 44
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(4),as.integer(trt.cov),as.integer(1))[[1]],ncol=44)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(4),as.integer(trt.cov),as.integer(1))[[1]],ncol=44)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(4),as.integer(trt.cov),as.integer(1))[[1]],ncol=44)
+   
+   
+                                         # copy across chip level variables into model matrix
+   nprobetypes <- 1
+   trt.cov <- rep(0:1,5)
+   ncols <- 10
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   trt.variables <- rnorm(10)
+   
+   matrix(.C("R_PLM_matrix_chiplevel",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.double(trt.variables),as.integer(1))[[1]],ncol=10)
+ 
+ 
+ ###
+ ### Build a few design matrices and compare with R model.matrix
+ ###
+ 
+ 
+   for (nprobetypes in 1:2){
+     for (narrays in 2:15){
+       for (nprobes in 2:20){
+         for (constraint.type in c("contr.sum","contr.treatment")){
+           if (constraint.type == "contr.sum"){
+             ct.type <- -1
+           } else {
+             ct.type <- 1
+           }
+ 
+           
+           ncols <- nprobes -1 + narrays
+           X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+           
+           X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(1),as.integer(1),as.integer(0),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+           
+           probe.effect <- factor(rep(1:nprobes,narrays*nprobetypes))
+           sample.effect <- factor(rep(rep(c(1:narrays),rep(nprobes,narrays)),nprobetypes))
+           if (nprobetypes == 2){
+             probe.type.effect <- factor(rep(1:2,c(narrays*nprobes,narrays*nprobes)))
+           } else {
+             probe.type.effect <- factor(rep(1,narrays*nprobes))
+           }
+           
+           if (any(X!=model.matrix(~ C(sample.effect,constraint.type) + C(probe.effect,constraint.type)))){
+             stop("Model matrix function problem ",narrays," ", nprobes, " ", nprobetypes)
+           }
+           
+           X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+           X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(0),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+           
+           if (any(X!=model.matrix(~ -1 + C(sample.effect,constraint.type) + C(probe.effect,constraint.type)))){
+             stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+           }
+           
+           ncols <- nprobes
+           X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+           X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(1),as.integer(0),as.integer(0),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+           
+           if (any(X!=model.matrix(~  C(probe.effect,constraint.type)))){
+             stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+           }
+           
+           
+           ncols <- nprobes
+           X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+           X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(0),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+           
+           if (any(X!=model.matrix(~-1+  C(probe.effect,constraint.type)))){
+             stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+           }
+           
+         }
+       }
+     }
+   }
+   
+ ###
+ ### Build a few more design matrices and compare with R model.matrix
+ ###
+ 
+   
+   for (narrays in 2:15){
+     for (nprobes in 2:20){
+       for (constraint.type in c("contr.sum","contr.treatment")){
+         probe.effect <- factor(rep(1:nprobes,narrays*nprobetypes))
+         sample.effect <- factor(rep(rep(c(1:narrays),rep(nprobes,narrays)),nprobetypes))
+         if (constraint.type == "contr.sum"){
+           ct.type <- -1
+         } else {
+           ct.type <- 1
+         }
+ 
+        
+         if (nprobetypes == 2){
+           probe.type.effect <- factor(rep(1:2,c(narrays*nprobes,narrays*nprobes)))
+         } else {
+           probe.type.effect <- factor(rep(1,narrays*nprobes))
+         }
+         ncols <- nprobetypes + nprobes -1
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(1),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~-1+ C(probe.type.effect,constraint.type) +  C(probe.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }
+         
+         ncols <- nprobetypes + nprobes -1
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(1),as.integer(0),as.integer(1),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~ C(probe.type.effect,constraint.type) +  C(probe.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }
+         
+         ncols <- narrays + nprobetypes + nprobes -2
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(1),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~ -1 + C(sample.effect,constraint.type) + C(probe.type.effect,constraint.type) +  C(probe.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }
+         
+         ncols <- narrays + nprobetypes + nprobes -2
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(1),as.integer(1),as.integer(1),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~ + C(sample.effect,constraint.type) + C(probe.type.effect,constraint.type) +  C(probe.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }
+         
+         ncols <- narrays + nprobetypes -1
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(1),as.integer(1),as.integer(1),as.integer(0),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~ C(sample.effect,constraint.type) + C(probe.type.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }    
+         
+         ncols <- narrays + nprobetypes -1
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(1),as.integer(0),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~ -1 + C(sample.effect,constraint.type) + C(probe.type.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }    
+         
+         ncols <- nprobetypes
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(1),as.integer(0),as.integer(1),as.integer(0),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~ C(probe.type.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }    
+       
+         ncols <- nprobetypes
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(1),as.integer(0),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~-1 +  C(probe.type.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }    
+         
+       }
+       
+       
+     }
+   }
+ 
+ 
+   narrays <- 2
+   nprobes <- 7
+   nprobetypes <- 2
+   
+   probe.effect <- factor(rep(1:nprobes,narrays*nprobetypes))
+   sample.effect <- factor(rep(rep(c(1:narrays),rep(nprobes,narrays)),nprobetypes))
+   if (constraint.type == "contr.sum"){
+     ct.type <- -1
+   } else {
+     ct.type <- 1
+   }
+   
+   
+   if (nprobetypes == 2){
+     probe.type.effect <- factor(rep(1:2,c(narrays*nprobes,narrays*nprobes)))
+   } else {
+     probe.type.effect <- factor(rep(1,narrays*nprobes))
+   }
+   
+ 
+   model.matrix(~-1 +probe.effect/probe.type.effect)
+ 
+ 
+   library(affyPLM)
+   output <- verify.output.param(list(weights = FALSE, residuals = FALSE, varcov = "none", resid.SE = TRUE))
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   library(affydata)
+   data(Dilution)
+ 
+   # fit a PM ~ samples model
+   R.model <- list(mmorpm.covariate=0,response.variable=1,which.parameter.types=as.integer(c(0,0,1,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0), probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+   sample.effect <- rep(1:4,c(16,16,16,16))
+   probe.effect <- rep(1:16,4)
+ 
+   library(MASS)
+   fit <- rlm(as.vector(log2(pm(Dilution)[1:16,])) ~ -1 + factor(sample.effect))
+   
+   if (any(Fitresults[[1]][1,] != coef(fit))){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   sample.effect <- rep(1:4,c(20,20,20,20))
+   probe.effect <- rep(1:20,4)
+   fit <- rlm(as.vector(log2(pm(Dilution)[201781:201800,])) ~ -1 + factor(sample.effect))
+    if (any(Fitresults[[1]][12625,] != coef(fit))){
+     stop("Problem in model fitting procedure")
+   }
+ 
+ 
+   # fit a samples + probes model
+   R.model <- list(mmorpm.covariate=0,response.variable=1,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0), probe.type.levels=list(),probe.trt.levels=list())
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   sample.effect <- rep(1:4,c(16,16,16,16))
+   probe.effect <- rep(1:16,4)
+ 
+   fit <- rlm(as.vector(log2(pm(Dilution)[1:16,])) ~ -1 + factor(sample.effect)+C(factor(probe.effect),"contr.sum"))
+   
+   if (any(abs(Fitresults[[1]][1,] -coef(fit)[1:4]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+    if (any(abs(as.vector(Fitresults[[2]][[1]]) - coef(fit)[5:19]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+ 
+ 
+   
+   sample.effect <- rep(1:4,c(20,20,20,20))
+   probe.effect <- rep(1:20,4)
+   fit <- rlm(as.vector(log2(pm(Dilution)[201781:201800,])) ~ -1 + factor(sample.effect)+C(factor(probe.effect),"contr.sum"))
+   
+   if (any(abs(Fitresults[[1]][12625,]  -coef(fit)[1:4])> 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   if (any(abs(as.vector(Fitresults[[2]][[12625]])- coef(fit)[5:23])>1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   # fit an MM ~ samples model
+   R.model <- list(mmorpm.covariate=0,response.variable=-1,which.parameter.types=as.integer(c(0,0,1,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0), probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+   sample.effect <- rep(1:4,c(16,16,16,16))
+   probe.effect <- rep(1:16,4)
+ 
+   library(MASS)
+   fit <- rlm(as.vector(log2(mm(Dilution)[1:16,])) ~ -1 + factor(sample.effect))
+   
+   if (any(abs(Fitresults[[1]][1,] - coef(fit)) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   sample.effect <- rep(1:4,c(20,20,20,20))
+   probe.effect <- rep(1:20,4)
+   fit <- rlm(as.vector(log2(mm(Dilution)[201781:201800,])) ~ -1 + factor(sample.effect))
+    if (any(abs(Fitresults[[1]][12625,] - coef(fit))>1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   # fit a MM ~ samples + probes model
+   R.model <- list(mmorpm.covariate=0,response.variable=-1,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0), probe.type.levels=list(),probe.trt.levels=list())
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   sample.effect <- rep(1:4,c(16,16,16,16))
+   probe.effect <- rep(1:16,4)
+ 
+   fit <- rlm(as.vector(log2(mm(Dilution)[1:16,])) ~ -1 + factor(sample.effect)+C(factor(probe.effect),"contr.sum"))
+   
+   if (any(abs(Fitresults[[1]][1,]-coef(fit)[1:4]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+    if (any(abs(as.vector(Fitresults[[2]][[1]])- coef(fit)[5:19])>1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+ 
+ 
+   
+   sample.effect <- rep(1:4,c(20,20,20,20))
+   probe.effect <- rep(1:20,4)
+   fit <- rlm(as.vector(log2(mm(Dilution)[201781:201800,])) ~ -1 + factor(sample.effect)+C(factor(probe.effect),"contr.sum"))
+   
+   if (any(abs(Fitresults[[1]][12625,]- coef(fit)[1:4])>1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   if (any(abs(as.vector(Fitresults[[2]][[12625]])-coef(fit)[5:23])>1e14)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+ 
+   # a treatment model
+   treatment.effect <- c(1,1,2,2)
+ 
+   covariates <- model.matrix(~ -1 + as.factor(treatment.effect))
+ 
+     R.model <- list(mmorpm.covariate=0,response.variable=-1,which.parameter.types=as.integer(c(0,1,0,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =covariates, probe.type.levels=list(),probe.trt.levels=list())
+   
+ Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   treatment.effect <- rep(c(1,1,2,2),c(16,16,16,16))
+   fit <- rlm(as.vector(log2(mm(Dilution)[1:16,])) ~ -1 + factor(treatment.effect))
+   
+   if (any(abs(Fitresults[[1]][1,]-coef(fit)[1:2]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+    output <-  verify.output.param(list(weights = FALSE, residuals = FALSE, varcov = "none", resid.SE = TRUE))
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+ 
+   # a treatment + probes model with contr.treatment constraint
+   R.model <- list(mmorpm.covariate=0,response.variable=-1,which.parameter.types=as.integer(c(0,1,0,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =covariates, probe.type.levels=list(),probe.trt.levels=list())
+   
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   
+   treatment.effect <- rep(c(1,1,2,2),c(20,20,20,20))
+   probe.effect <- rep(1:20,4)
+   fit <- rlm(as.vector(log2(mm(Dilution)[201761:201780,])) ~ -1 + factor(treatment.effect)+C(factor(probe.effect),"contr.treatment"))
+   
+   if (any(abs(Fitresults[[1]][12624,]-coef(fit)[1:2]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   if (any(abs(as.vector(Fitresults[[2]][[12624]])-coef(fit)[3:21])>1e14)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+ 
+   
+   
+   # MM + samples + probes
+   R.model <- list(mmorpm.covariate=1,response.variable=1,which.parameter.types=as.integer(c(0,0,0,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0), probe.type.levels=list(),probe.trt.levels=list())
+ 
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   
+  sample.effect <- rep(1:4,c(16,16,16,16))
+   probe.effect <- rep(1:16,4)
+ 
+   fit <- rlm(as.vector(log2(pm(Dilution)[1:16,])) ~ -1 + as.vector(log2(mm(Dilution)[1:16,])))
+   
+ 
+   if (any(abs(as.vector(Fitresults[[6]][[1]]) - coef(fit)) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   R.model <- list(mmorpm.covariate=1,response.variable=1,which.parameter.types=as.integer(c(0,0,1,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+ 
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   fit <- rlm(as.vector(log2(pm(Dilution)[1:16,])) ~ -1 + as.vector(log2(mm(Dilution)[1:16,]))+ as.factor(sample.effect))
+   if (any(abs(as.vector(Fitresults[[6]][[1]]) - coef(fit)[1]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+  if (any(abs(as.vector(Fitresults[[1]][1,]) - coef(fit)[2:5]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   R.model <- list(mmorpm.covariate=1,response.variable=1,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+ 
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   fit <- rlm(as.vector(log2(pm(Dilution)[1:16,])) ~ -1 + as.vector(log2(mm(Dilution)[1:16,]))+ as.factor(sample.effect) + C(as.factor(probe.effect),"contr.sum"))
+   if (any(abs(as.vector(Fitresults[[6]][[1]]) - coef(fit)[1]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   if (any(abs(as.vector(Fitresults[[1]][1,]) - coef(fit)[2:5]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+ 
+   ## PM and MM are response
+ 
+   
+   sample.effect <- rep(1:4,c(32,32,32,32))
+   probe.effect <- rep(1:16,8)
+   
+ 
+   
+   # PMMM ~ -1 + samples
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   
+   fit <- rlm(as.vector(rbind(log2(pm(Dilution)[1:16,]),log2(mm(Dilution)[1:16,]))) ~ -1 + as.factor(sample.effect))
+   if (any(abs(as.vector(Fitresults[[1]][1,]) - coef(fit)) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   # PMMM ~ -1 + samples +PROBES
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   fit <- rlm(as.vector(rbind(log2(pm(Dilution)[1:16,]),log2(mm(Dilution)[1:16,]))) ~ -1 + as.factor(sample.effect)+C(as.factor(probe.effect),"contr.sum") )
+   if (any(abs(as.vector(Fitresults[[1]][1,]) - coef(fit)[1:4]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   # a probe.type effect
+   probe.type.effect <- rep(rep(1:2,c(16,16)),4)
+ 
+   # PMMM ~ -1 + samples + probe.type + PROBES
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,1,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,-1,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   fit <- rlm(as.vector(rbind(log2(pm(Dilution)[1:16,]),log2(mm(Dilution)[1:16,]))) ~ -1 + as.factor(sample.effect)+ C(as.factor(probe.type.effect),"contr.sum")+ C(as.factor(probe.effect),"contr.sum") )
+   
+    if (any(abs(as.vector(Fitresults[[1]][1,]) - coef(fit)[1:4]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+    if (any(abs(as.vector(Fitresults[[6]][1,]) - coef(fit)[5]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+ 
+ 
+   #### store weights PM ~ -1 + samples
+ 
+   output <-  verify.output.param(list(weights = TRUE, residuals = TRUE, varcov = "none", resid.SE = TRUE))
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=1,which.parameter.types=as.integer(c(0,0,1,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+  
+ 
+ #### store weights PMMM ~ -1 + samples
+ 
+   output <-  verify.output.param(list(weights = TRUE, residuals = TRUE, varcov = "none", resid.SE = TRUE))
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+ #### store weights PMMM ~ -1 + samples + probe.type + probes
+ 
+   output <- verify.output.param(list(weights = TRUE, residuals = TRUE, varcov ="none", resid.SE = TRUE))
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,1,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,1,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   ## PM ~ -1 + treatment + probes in treatment
+   output <- verify.output.param(list(weights = TRUE, residuals = TRUE, varcov = "none", resid.SE = TRUE))
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   treatment.effect <- c(1,1,2,2)
+ 
+   covariates <- model.matrix(~ -1 + as.factor(treatment.effect))
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=1,which.parameter.types=as.integer(c(0,1,0,0,1)),strata=as.integer(c(0,0,0,0,2)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =covariates,probe.type.levels=list(),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   ## PMMM ~ -1 + treatment + probes in treatment
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   treatment.effect <- c(1,1,2,2)
+ 
+   covariates <- model.matrix(~ -1 + as.factor(treatment.effect))
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,1,0,0,1)),strata=as.integer(c(0,0,0,0,2)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =covariates,probe.type.levels=list(),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+    ## PMMM ~ -1 + treatment + probe.effect in treatment
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   treatment.effect <- c(1,1,2,2)
+ 
+   covariates <- model.matrix(~ -1 + as.factor(treatment.effect))
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,1,0,1,0)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,-1,0)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =covariates,probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+    ## PMMM ~ -1+ probes
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+    ## PMMM ~ -1+ probes.type
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,1,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   ## PMMM ~ -1+ probes.type + probes
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,1,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+     ## PMMM ~ -1+ probes.type + probes     with both within treatment factor
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,1,1)),strata=as.integer(c(0,0,0,2,2)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+     ## PMMM ~ -1+ probes.type + probes     with both within treatment factor and probes also within probe.type
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,1,1)),strata=as.integer(c(0,0,0,2,4)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+   ## PMMM ~ -1+ probes.type + probes     probe.types within treatment factor and probes also within probe.type
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,1,1)),strata=as.integer(c(0,0,0,2,3)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+  ## PMMM ~ -1+ probes.type + probes     probe.types within samples and probes also within probe.type
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,1,1)),strata=as.integer(c(0,0,0,1,3)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+ 
+   ## PMMM ~ intercept + probes.type + probes     probe.types within samples and probes also within probe.type
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(1,0,0,1,1)),strata=as.integer(c(0,0,0,1,3)),constraints=as.integer(c(0,0,0,-1,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+   
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+     ## PMMM ~ intercept + probes      probes also within probe.type
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(1,0,0,0,1)),strata=as.integer(c(0,0,0,0,3)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+   
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+      ## PMMM ~ -1+ probes      probes also within probe.type
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,0,1)),strata=as.integer(c(0,0,0,0,3)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+   
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   # now play with varcov output
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+   
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+  # now play with varcov output and treatment
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+  treatment.effect <- c(1,1,2,2)
+ 
+   covariates <- model.matrix(~ -1 + as.factor(treatment.effect))
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,1,0,0,0)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =covariates,probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   
+ 
+   # now play with varcov output and an intercept
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(1,0,1,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,-1,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+   
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+ 
+  # now play with varcov output and treatment and intercept
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+  treatment.effect <- c(1,1,2,2)
+ 
+   covariates <- matrix(model.matrix(~ as.factor(treatment.effect))[,2])
+   colnames(covariates) <- "trt_2"
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(1,1,0,0,0)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =covariates,probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   
+ 
+  # now play with varcov all option output and treatment and intercept
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+  treatment.effect <- c(1,1,2,2)
+    
+   covariates <- matrix(model.matrix(~ as.factor(treatment.effect))[,2])
+   colnames(covariates) <- "trt_2"
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(1,1,0,0,0)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =covariates,probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+  # now play with varcov all option output and samples and intercept
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(1,0,1,0,1)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,-1,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+        # now play with varcov all option output and samples and intercept, MM covarite
+     output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=1,response.variable=1,which.parameter.types=as.integer(c(1,0,1,0,1)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,-1,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+ 
+ 
+ 
+ 
+ 
+   ## now play with varcov all option output and samples and intercept, MM covariate and input chip weights
+   output <- verify.output.param(list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE))
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=c(1,1,0.5,0.5),weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=1,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   ## now play with varcov all option output and samples and intercept, MM covariate and input chip weights
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=runif(201800))
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=1,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+ 
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=c(rep(c(1,0.5),c(201800,201800))))
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   
+ 
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="cuberoot", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   
+ 
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log10", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+ }
> 
> 
> 
> if (test.PLM.modelmatrix){
+ 
+   library(affyPLM);data(Dilution)
+   
+   #PLM.designmatrix3(Dilution)
+   
+   #PLM.designmatrix3(Dilution,model=MM ~ PM -1 + samples +probe.type:probes)
+   
+   #PLM.designmatrix3(Dilution,model=MM ~ PM -1 + samples:probe.type + liver:probe.type:probes + liver:samples)
+   #PLM.designmatrix3(Dilution,model=MM ~ PM + samples:probe.type + liver:probe.type:probes + liver + samples)
+ 
+ 
+ 
+ 
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   #blah <- c(1,5,5,1)
+   #R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ probes + blah,constraint.type=c(probes="contr.sum"))
+   #R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ -1 + blah:probe.type)
+   #R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ -1 +probes:probe.type)
+   #R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ -1 +probes:blah)
+   #R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ -1 +probes:probe.type:blah)
+   #output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+ #  R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ samples,constraint.type=c(samples="contr.sum"))
+ #  R.model <-  PLM.designmatrix3(Dilution,model=PMMM ~ blah)
+ #   R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ -1 + samples)
+   #R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ probes + blah)
+   #R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ probes + blah)
+   #Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   library(affyPLM);data(Dilution)
+    output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ probe.type + probe.type:probes + samples)
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   library(affyPLM);data(Dilution)
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ samples:probe.type + probe.type:probes + samples)
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   
+  output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   blah <- c(1,2,2)
+   R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ blah:probe.type + probe.type:probes + samples)
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   blah <- c(1,2,2)
+   R.model <- PLM.designmatrix3(Dilution,model=PM ~ -1 + probes + MM + blah)
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   blah <- c(1,2,2)
+   R.model <- PLM.designmatrix3(Dilution,model=PM ~ -1 + probes + MM + samples)
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+ 
+ 
+ 
+ 
+ #test some of the verification functions
+ 
+ 
+   output <- verify.output.param()
+   modelparam <- verify.model.param(Dilution,PM ~ -1 + probes + MM + samples)
+   R.model <- PLM.designmatrix3(Dilution,model=PM ~ -1 + probes + MM + samples)
+  
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   ##verify.model.param(Dilution,PM ~ -1 + probes + MM + samples,model.param=list(weights.probe=rep(1,10)))
+ 
+    modelparam <- verify.model.param(Dilution,PMMM ~ -1 + probes + samples,model.param=list(weights.chip=c(1,2,3),weights.probe=rep(1,2400*2)))
+   R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ -1 + probes + samples)
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+   
+  modelparam <- verify.model.param(Dilution,PM ~ -1 + probes + samples,model.param=list())
+   R.model <- PLM.designmatrix3(Dilution,model=PM ~ -1 + probes + samples)
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   ## probes <- rep(1:16,3)
+   ##  chips <- rep(1:3,c(16,16,16))
+ 
+   ## library(MASS)
+   
+   ##fit <- rlm(log2(as.vector(pm(Dilution,"HG2188-HT2258_at"))) ~ -1 + as.factor(chips) + C(as.factor(probes),"contr.sum"))
+   
+ 
+ #test creating a PLMset based on the output from rlm_PLMset
+ 
+ ###  x <- new("PLMset")
+ ###  x@chip.coefs=Fitresults[[1]]
+ ###  x@probe.coefs= Fitresults[[2]]
+ ###  x@weights=Fitresults[[3]]
+ ###  x@se.chip.coefs=Fitresults[[4]]
+ ###  x@se.probe.coefs=Fitresults[[5]]
+ ###  x@exprs=Fitresults[[6]]
+ ###  x@se.exprs=Fitresults[[7]]
+ ###  x@residuals=Fitresults[[8]]
+ ###  x@residualSE=Fitresults[[9]]
+ ###  x@varcov = Fitresults[[10]]
+ ###  x@cdfName = Dilution@cdfName
+  ### x@phenoData = Dilution@phenoData
+  ### x@annotation = Dilution@annotation
+ ###  x@description = Dilution@description
+ ###  x@notes = Dilution@notes
+ ###  x@nrow= Dilution@nrow
+ ###  x@ncol= Dilution@ncol
+ ### x@model.description = c(x@model.description, list(R.model=R.model))
+ ###  image(x)
+ 
+ 
+ 
+ 
+ ###  data(Dilution)
+ ###  output <- verify.output.param()
+ ###  modelparam <- verify.model.param(Dilution,PMMM ~ -1 + probe.type:probes + samples + samples:probe.type,model.param=list())
+ ###  R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ -1 + probe.type:probes + samples+ samples:probe.type)
+ ###  Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ ###  output <- verify.output.param()
+ ###  modelparam <- verify.model.param(Dilution,MM ~ -1 + probes + samples,model.param=list())
+ ###  R.model <- PLM.designmatrix3(Dilution,model=MM ~ -1 + probes + samples)
+ ###  Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   
+ 
+ ###  x <- new("PLMset")
+  ### x@chip.coefs=Fitresults[[1]]
+ ###  x@probe.coefs= Fitresults[[2]]
+ ###  x@weights=Fitresults[[3]]
+ ###  x@se.chip.coefs=Fitresults[[4]]
+ ###  x@se.probe.coefs=Fitresults[[5]]
+ ###  x@exprs=Fitresults[[6]]
+ ###  x@se.exprs=Fitresults[[7]]
+  ### x@residuals=Fitresults[[8]]
+ ###  x@residualSE=Fitresults[[9]]
+ ###  x@varcov = Fitresults[[10]]
+ ###  x@cdfName = Dilution@cdfName
+ ###  x@phenoData = Dilution@phenoData
+ ###  x@annotation = Dilution@annotation
+ ###  x@description = Dilution@description
+ ###  x@notes = Dilution@notes
+ ###  x@nrow= Dilution@nrow
+ ###  x@ncol= Dilution@ncol
+ ###  x@model.description = c(x@model.description, list(R.model=R.model))
+ ###  image(x)
+ ###  image(x,type="pos.resids")
+ ###  image(x,type="neg.resids")
+ ###  image(x,type="sign.resids")
+ 
+ ###  resid(x,"1091_at")
+ 
+ 
+ 
+ ###  weights(x,c("1091_at","1092_at"))
+ 
+ 
+ ###  image(x,type="resids",standardize=TRUE)
+ 
+ 
+ 
+ 
+   
+   
+ }
> 
> 
> 
> 
> 
> if (test.rlm){
+ 
+ 
+   library(affyPLM);data(Dilution)
+ 
+   y <- as.vector(log2(pm(Dilution)[1:16,]))
+ 
+   w <- runif(64)
+ 
+   probes <- rep(1:16,4)
+   samples <- rep(1:4,c(16,16,16,16))
+ 
+   x <- model.matrix( ~ -1 + as.factor(samples) + C(as.factor(probes),"contr.sum"))
+   x <- as.vector(x)
+ 
+   cols <- 19
+   rows <- 64
+   
+ 
+ #  rlm_wfit_R(double *x, double *y, double *w, int *rows, int *cols, double *out_beta, double *out_resids, double *out_weights)
+ 
+   fit1 <-.C("rlm_wfit_R",as.double(x),as.double(y),as.double(w),as.integer(rows),as.integer(cols),double(cols),double(rows),double(rows))
+ 
+ 
+   library(MASS)
+ 
+   fit2 <- rlm(y ~ -1 + as.factor(samples) + C(as.factor(probes),"contr.sum"),weights=w,wt.method="case")
+ 
+   if (any(abs(coef(fit2) - fit1[[6]]) > 10e-14)){
+     stop("Weighted RLM did not work")
+   }
+ 
+ 
+ 
+ 
+ 
+   y <- as.vector(log2(pm(Dilution,"1001_at")))
+   x <- as.vector(log2(mm(Dilution,"1001_at")))
+ 
+   rlm(y ~ -1 + x + as.factor(samples) + C(as.factor(probes),"contr.sum"))
+ 
+ 
+ 
+ 
+ 
+ 
+ 
+ 
+ 
+ 
+   
+ }
> 
> 
> 
> 
> proc.time()
   user  system elapsed 
   1.82    0.06    1.87 

affyPLM.Rcheck/tests_x64/C_code_tests.Rout


R version 4.0.2 (2020-06-22) -- "Taking Off Again"
Copyright (C) 2020 The R Foundation for Statistical Computing
Platform: x86_64-w64-mingw32/x64 (64-bit)

R is free software and comes with ABSOLUTELY NO WARRANTY.
You are welcome to redistribute it under certain conditions.
Type 'license()' or 'licence()' for distribution details.

R is a collaborative project with many contributors.
Type 'contributors()' for more information and
'citation()' on how to cite R or R packages in publications.

Type 'demo()' for some demos, 'help()' for on-line help, or
'help.start()' for an HTML browser interface to help.
Type 'q()' to quit R.

> ####
> #### This code is messy, possibly incomplete and only for
> #### the use of developers.
> ####
> ####
> 
> test.c.code <-  FALSE
> test.PLM.modelmatrix <- FALSE
> test.rlm <- FALSE
> 
> if (test.c.code){
+   
+   library(affyPLM)
+   narrays <- 10
+   nprobes <- 11
+   nprobetypes <- 2
+   ncols <- 10
+   
+   MMs <- rnorm(narrays*nprobes*nprobetypes)
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   
+                                         #test making intercept column
+   matrix(.C("R_PLM_matrix_intercept",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),0)[[1]],ncol=10)
+   
+                                         #test making an MM covariate column
+   matrix(.C("R_PLM_matrix_MM",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(1),as.double(MMs))[[1]],ncol=10)
+   
+                                         # sample effect aka chip effect, aka expression values
+   matrix(.C("R_PLM_matrix_sample_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0))[[1]],ncol=10)
+   matrix(.C("R_PLM_matrix_sample_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1))[[1]],ncol=10)
+   matrix(.C("R_PLM_matrix_sample_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1))[[1]],ncol=10)
+   
+   
+   
+                                         #probe-type parameter overall
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(0),integer(narrays),as.integer(1))[[1]],ncol=10)
+   
+                                         #probe-type parameter within sample
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(1),integer(narrays),as.integer(1))[[1]],ncol=10)
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(1),integer(narrays),as.integer(1))[[1]],ncol=10)
+   ncols <- 20
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(1),integer(narrays),as.integer(0))[[1]],ncol=20)
+   
+   
+                                         #probe-type-parameter within a chip-level factor (eg treatment, or genotype variable)
+   trt.cov <- rep(0:1,5)
+   ncols <- 10
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(2),as.integer(trt.cov),as.integer(1))[[1]],ncol=10)
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(2),as.integer(trt.cov),as.integer(1))[[1]],ncol=10)
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(2),as.integer(trt.cov),as.integer(1))[[1]],ncol=10)
+   
+   trt.cov <- rep(0:4,2)
+   matrix(.C("R_PLM_matrix_probe_type_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(2),as.integer(trt.cov),as.integer(4))[[1]],ncol=10)
+   
+   
+   
+   
+                                         #probe effects - overall
+   ncols <- 11
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   
+   
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(0),as.integer(trt.cov),as.integer(4))[[1]],ncol=11)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(0),as.integer(trt.cov),as.integer(4))[[1]],ncol=11)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(0),as.integer(trt.cov),as.integer(4))[[1]],ncol=11)
+   
+   
+   
+                                         #probe effects within treatment or genotype factor
+   trt.cov <- rep(0:1,5)
+   ncols <- 22
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(2),as.integer(trt.cov),as.integer(1))[[1]],ncol=22)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(2),as.integer(trt.cov),as.integer(1))[[1]],ncol=22)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(2),as.integer(trt.cov),as.integer(1))[[1]],ncol=22)
+   
+   
+                                         #probe effects within probetype
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(3),as.integer(trt.cov),as.integer(1))[[1]],ncol=22)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(3),as.integer(trt.cov),as.integer(1))[[1]],ncol=22)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(3),as.integer(trt.cov),as.integer(1))[[1]],ncol=22)
+   
+   
+                                         #probe effects within probetype within treatment or genotype factor variable
+   trt.cov <- rep(0:1,5)
+   ncols <- 44
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(4),as.integer(trt.cov),as.integer(1))[[1]],ncol=44)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(4),as.integer(trt.cov),as.integer(1))[[1]],ncol=44)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(4),as.integer(trt.cov),as.integer(1))[[1]],ncol=44)
+   
+   nprobetypes <- 1
+   trt.cov <- rep(0:1,5)
+   ncols <- 44
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(4),as.integer(trt.cov),as.integer(1))[[1]],ncol=44)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(4),as.integer(trt.cov),as.integer(1))[[1]],ncol=44)
+   matrix(.C("R_PLM_matrix_probe_effect",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(-1),as.integer(4),as.integer(trt.cov),as.integer(1))[[1]],ncol=44)
+   
+   
+                                         # copy across chip level variables into model matrix
+   nprobetypes <- 1
+   trt.cov <- rep(0:1,5)
+   ncols <- 10
+   X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+   trt.variables <- rnorm(10)
+   
+   matrix(.C("R_PLM_matrix_chiplevel",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.double(trt.variables),as.integer(1))[[1]],ncol=10)
+ 
+ 
+ ###
+ ### Build a few design matrices and compare with R model.matrix
+ ###
+ 
+ 
+   for (nprobetypes in 1:2){
+     for (narrays in 2:15){
+       for (nprobes in 2:20){
+         for (constraint.type in c("contr.sum","contr.treatment")){
+           if (constraint.type == "contr.sum"){
+             ct.type <- -1
+           } else {
+             ct.type <- 1
+           }
+ 
+           
+           ncols <- nprobes -1 + narrays
+           X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+           
+           X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(1),as.integer(1),as.integer(0),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+           
+           probe.effect <- factor(rep(1:nprobes,narrays*nprobetypes))
+           sample.effect <- factor(rep(rep(c(1:narrays),rep(nprobes,narrays)),nprobetypes))
+           if (nprobetypes == 2){
+             probe.type.effect <- factor(rep(1:2,c(narrays*nprobes,narrays*nprobes)))
+           } else {
+             probe.type.effect <- factor(rep(1,narrays*nprobes))
+           }
+           
+           if (any(X!=model.matrix(~ C(sample.effect,constraint.type) + C(probe.effect,constraint.type)))){
+             stop("Model matrix function problem ",narrays," ", nprobes, " ", nprobetypes)
+           }
+           
+           X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+           X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(0),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+           
+           if (any(X!=model.matrix(~ -1 + C(sample.effect,constraint.type) + C(probe.effect,constraint.type)))){
+             stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+           }
+           
+           ncols <- nprobes
+           X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+           X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(1),as.integer(0),as.integer(0),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+           
+           if (any(X!=model.matrix(~  C(probe.effect,constraint.type)))){
+             stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+           }
+           
+           
+           ncols <- nprobes
+           X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+           X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(0),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+           
+           if (any(X!=model.matrix(~-1+  C(probe.effect,constraint.type)))){
+             stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+           }
+           
+         }
+       }
+     }
+   }
+   
+ ###
+ ### Build a few more design matrices and compare with R model.matrix
+ ###
+ 
+   
+   for (narrays in 2:15){
+     for (nprobes in 2:20){
+       for (constraint.type in c("contr.sum","contr.treatment")){
+         probe.effect <- factor(rep(1:nprobes,narrays*nprobetypes))
+         sample.effect <- factor(rep(rep(c(1:narrays),rep(nprobes,narrays)),nprobetypes))
+         if (constraint.type == "contr.sum"){
+           ct.type <- -1
+         } else {
+           ct.type <- 1
+         }
+ 
+        
+         if (nprobetypes == 2){
+           probe.type.effect <- factor(rep(1:2,c(narrays*nprobes,narrays*nprobes)))
+         } else {
+           probe.type.effect <- factor(rep(1,narrays*nprobes))
+         }
+         ncols <- nprobetypes + nprobes -1
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(1),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~-1+ C(probe.type.effect,constraint.type) +  C(probe.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }
+         
+         ncols <- nprobetypes + nprobes -1
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(1),as.integer(0),as.integer(1),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~ C(probe.type.effect,constraint.type) +  C(probe.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }
+         
+         ncols <- narrays + nprobetypes + nprobes -2
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(1),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~ -1 + C(sample.effect,constraint.type) + C(probe.type.effect,constraint.type) +  C(probe.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }
+         
+         ncols <- narrays + nprobetypes + nprobes -2
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(1),as.integer(1),as.integer(1),as.integer(1),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~ + C(sample.effect,constraint.type) + C(probe.type.effect,constraint.type) +  C(probe.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }
+         
+         ncols <- narrays + nprobetypes -1
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(1),as.integer(1),as.integer(1),as.integer(0),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~ C(sample.effect,constraint.type) + C(probe.type.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }    
+         
+         ncols <- narrays + nprobetypes -1
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(1),as.integer(1),as.integer(0),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~ -1 + C(sample.effect,constraint.type) + C(probe.type.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }    
+         
+         ncols <- nprobetypes
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(1),as.integer(0),as.integer(1),as.integer(0),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~ C(probe.type.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }    
+       
+         ncols <- nprobetypes
+         X <- matrix(0,narrays*nprobes*nprobetypes,ncols)
+         X <- matrix(.C("R_PLM_Matrix_constructtest",as.double(as.vector(X)), as.integer(narrays),as.integer(nprobes),as.integer(nprobetypes),as.integer(0),as.integer(0),as.integer(1),as.integer(0),as.integer(ct.type))[[1]],ncol=ncols)
+         
+         if (any(X!=model.matrix(~-1 +  C(probe.type.effect,constraint.type)))){
+           stop("Model matrix function problem ",narrays," ", nprobes," ", nprobetypes)
+         }    
+         
+       }
+       
+       
+     }
+   }
+ 
+ 
+   narrays <- 2
+   nprobes <- 7
+   nprobetypes <- 2
+   
+   probe.effect <- factor(rep(1:nprobes,narrays*nprobetypes))
+   sample.effect <- factor(rep(rep(c(1:narrays),rep(nprobes,narrays)),nprobetypes))
+   if (constraint.type == "contr.sum"){
+     ct.type <- -1
+   } else {
+     ct.type <- 1
+   }
+   
+   
+   if (nprobetypes == 2){
+     probe.type.effect <- factor(rep(1:2,c(narrays*nprobes,narrays*nprobes)))
+   } else {
+     probe.type.effect <- factor(rep(1,narrays*nprobes))
+   }
+   
+ 
+   model.matrix(~-1 +probe.effect/probe.type.effect)
+ 
+ 
+   library(affyPLM)
+   output <- verify.output.param(list(weights = FALSE, residuals = FALSE, varcov = "none", resid.SE = TRUE))
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   library(affydata)
+   data(Dilution)
+ 
+   # fit a PM ~ samples model
+   R.model <- list(mmorpm.covariate=0,response.variable=1,which.parameter.types=as.integer(c(0,0,1,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0), probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+   sample.effect <- rep(1:4,c(16,16,16,16))
+   probe.effect <- rep(1:16,4)
+ 
+   library(MASS)
+   fit <- rlm(as.vector(log2(pm(Dilution)[1:16,])) ~ -1 + factor(sample.effect))
+   
+   if (any(Fitresults[[1]][1,] != coef(fit))){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   sample.effect <- rep(1:4,c(20,20,20,20))
+   probe.effect <- rep(1:20,4)
+   fit <- rlm(as.vector(log2(pm(Dilution)[201781:201800,])) ~ -1 + factor(sample.effect))
+    if (any(Fitresults[[1]][12625,] != coef(fit))){
+     stop("Problem in model fitting procedure")
+   }
+ 
+ 
+   # fit a samples + probes model
+   R.model <- list(mmorpm.covariate=0,response.variable=1,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0), probe.type.levels=list(),probe.trt.levels=list())
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   sample.effect <- rep(1:4,c(16,16,16,16))
+   probe.effect <- rep(1:16,4)
+ 
+   fit <- rlm(as.vector(log2(pm(Dilution)[1:16,])) ~ -1 + factor(sample.effect)+C(factor(probe.effect),"contr.sum"))
+   
+   if (any(abs(Fitresults[[1]][1,] -coef(fit)[1:4]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+    if (any(abs(as.vector(Fitresults[[2]][[1]]) - coef(fit)[5:19]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+ 
+ 
+   
+   sample.effect <- rep(1:4,c(20,20,20,20))
+   probe.effect <- rep(1:20,4)
+   fit <- rlm(as.vector(log2(pm(Dilution)[201781:201800,])) ~ -1 + factor(sample.effect)+C(factor(probe.effect),"contr.sum"))
+   
+   if (any(abs(Fitresults[[1]][12625,]  -coef(fit)[1:4])> 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   if (any(abs(as.vector(Fitresults[[2]][[12625]])- coef(fit)[5:23])>1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   # fit an MM ~ samples model
+   R.model <- list(mmorpm.covariate=0,response.variable=-1,which.parameter.types=as.integer(c(0,0,1,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0), probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+   sample.effect <- rep(1:4,c(16,16,16,16))
+   probe.effect <- rep(1:16,4)
+ 
+   library(MASS)
+   fit <- rlm(as.vector(log2(mm(Dilution)[1:16,])) ~ -1 + factor(sample.effect))
+   
+   if (any(abs(Fitresults[[1]][1,] - coef(fit)) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   sample.effect <- rep(1:4,c(20,20,20,20))
+   probe.effect <- rep(1:20,4)
+   fit <- rlm(as.vector(log2(mm(Dilution)[201781:201800,])) ~ -1 + factor(sample.effect))
+    if (any(abs(Fitresults[[1]][12625,] - coef(fit))>1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   # fit a MM ~ samples + probes model
+   R.model <- list(mmorpm.covariate=0,response.variable=-1,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0), probe.type.levels=list(),probe.trt.levels=list())
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   sample.effect <- rep(1:4,c(16,16,16,16))
+   probe.effect <- rep(1:16,4)
+ 
+   fit <- rlm(as.vector(log2(mm(Dilution)[1:16,])) ~ -1 + factor(sample.effect)+C(factor(probe.effect),"contr.sum"))
+   
+   if (any(abs(Fitresults[[1]][1,]-coef(fit)[1:4]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+    if (any(abs(as.vector(Fitresults[[2]][[1]])- coef(fit)[5:19])>1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+ 
+ 
+   
+   sample.effect <- rep(1:4,c(20,20,20,20))
+   probe.effect <- rep(1:20,4)
+   fit <- rlm(as.vector(log2(mm(Dilution)[201781:201800,])) ~ -1 + factor(sample.effect)+C(factor(probe.effect),"contr.sum"))
+   
+   if (any(abs(Fitresults[[1]][12625,]- coef(fit)[1:4])>1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   if (any(abs(as.vector(Fitresults[[2]][[12625]])-coef(fit)[5:23])>1e14)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+ 
+   # a treatment model
+   treatment.effect <- c(1,1,2,2)
+ 
+   covariates <- model.matrix(~ -1 + as.factor(treatment.effect))
+ 
+     R.model <- list(mmorpm.covariate=0,response.variable=-1,which.parameter.types=as.integer(c(0,1,0,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =covariates, probe.type.levels=list(),probe.trt.levels=list())
+   
+ Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   treatment.effect <- rep(c(1,1,2,2),c(16,16,16,16))
+   fit <- rlm(as.vector(log2(mm(Dilution)[1:16,])) ~ -1 + factor(treatment.effect))
+   
+   if (any(abs(Fitresults[[1]][1,]-coef(fit)[1:2]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+    output <-  verify.output.param(list(weights = FALSE, residuals = FALSE, varcov = "none", resid.SE = TRUE))
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+ 
+   # a treatment + probes model with contr.treatment constraint
+   R.model <- list(mmorpm.covariate=0,response.variable=-1,which.parameter.types=as.integer(c(0,1,0,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =covariates, probe.type.levels=list(),probe.trt.levels=list())
+   
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   
+   treatment.effect <- rep(c(1,1,2,2),c(20,20,20,20))
+   probe.effect <- rep(1:20,4)
+   fit <- rlm(as.vector(log2(mm(Dilution)[201761:201780,])) ~ -1 + factor(treatment.effect)+C(factor(probe.effect),"contr.treatment"))
+   
+   if (any(abs(Fitresults[[1]][12624,]-coef(fit)[1:2]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   if (any(abs(as.vector(Fitresults[[2]][[12624]])-coef(fit)[3:21])>1e14)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+ 
+   
+   
+   # MM + samples + probes
+   R.model <- list(mmorpm.covariate=1,response.variable=1,which.parameter.types=as.integer(c(0,0,0,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0), probe.type.levels=list(),probe.trt.levels=list())
+ 
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   
+  sample.effect <- rep(1:4,c(16,16,16,16))
+   probe.effect <- rep(1:16,4)
+ 
+   fit <- rlm(as.vector(log2(pm(Dilution)[1:16,])) ~ -1 + as.vector(log2(mm(Dilution)[1:16,])))
+   
+ 
+   if (any(abs(as.vector(Fitresults[[6]][[1]]) - coef(fit)) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   R.model <- list(mmorpm.covariate=1,response.variable=1,which.parameter.types=as.integer(c(0,0,1,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+ 
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   fit <- rlm(as.vector(log2(pm(Dilution)[1:16,])) ~ -1 + as.vector(log2(mm(Dilution)[1:16,]))+ as.factor(sample.effect))
+   if (any(abs(as.vector(Fitresults[[6]][[1]]) - coef(fit)[1]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+  if (any(abs(as.vector(Fitresults[[1]][1,]) - coef(fit)[2:5]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   R.model <- list(mmorpm.covariate=1,response.variable=1,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+ 
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   fit <- rlm(as.vector(log2(pm(Dilution)[1:16,])) ~ -1 + as.vector(log2(mm(Dilution)[1:16,]))+ as.factor(sample.effect) + C(as.factor(probe.effect),"contr.sum"))
+   if (any(abs(as.vector(Fitresults[[6]][[1]]) - coef(fit)[1]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   if (any(abs(as.vector(Fitresults[[1]][1,]) - coef(fit)[2:5]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+ 
+   ## PM and MM are response
+ 
+   
+   sample.effect <- rep(1:4,c(32,32,32,32))
+   probe.effect <- rep(1:16,8)
+   
+ 
+   
+   # PMMM ~ -1 + samples
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   
+   fit <- rlm(as.vector(rbind(log2(pm(Dilution)[1:16,]),log2(mm(Dilution)[1:16,]))) ~ -1 + as.factor(sample.effect))
+   if (any(abs(as.vector(Fitresults[[1]][1,]) - coef(fit)) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   # PMMM ~ -1 + samples +PROBES
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   fit <- rlm(as.vector(rbind(log2(pm(Dilution)[1:16,]),log2(mm(Dilution)[1:16,]))) ~ -1 + as.factor(sample.effect)+C(as.factor(probe.effect),"contr.sum") )
+   if (any(abs(as.vector(Fitresults[[1]][1,]) - coef(fit)[1:4]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+   # a probe.type effect
+   probe.type.effect <- rep(rep(1:2,c(16,16)),4)
+ 
+   # PMMM ~ -1 + samples + probe.type + PROBES
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,1,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,-1,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   fit <- rlm(as.vector(rbind(log2(pm(Dilution)[1:16,]),log2(mm(Dilution)[1:16,]))) ~ -1 + as.factor(sample.effect)+ C(as.factor(probe.type.effect),"contr.sum")+ C(as.factor(probe.effect),"contr.sum") )
+   
+    if (any(abs(as.vector(Fitresults[[1]][1,]) - coef(fit)[1:4]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+    if (any(abs(as.vector(Fitresults[[6]][1,]) - coef(fit)[5]) > 1e-13)){
+     stop("Problem in model fitting procedure")
+   }
+ 
+ 
+ 
+   #### store weights PM ~ -1 + samples
+ 
+   output <-  verify.output.param(list(weights = TRUE, residuals = TRUE, varcov = "none", resid.SE = TRUE))
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=1,which.parameter.types=as.integer(c(0,0,1,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+  
+ 
+ #### store weights PMMM ~ -1 + samples
+ 
+   output <-  verify.output.param(list(weights = TRUE, residuals = TRUE, varcov = "none", resid.SE = TRUE))
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,0,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+ #### store weights PMMM ~ -1 + samples + probe.type + probes
+ 
+   output <- verify.output.param(list(weights = TRUE, residuals = TRUE, varcov ="none", resid.SE = TRUE))
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,1,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,1,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   ## PM ~ -1 + treatment + probes in treatment
+   output <- verify.output.param(list(weights = TRUE, residuals = TRUE, varcov = "none", resid.SE = TRUE))
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   treatment.effect <- c(1,1,2,2)
+ 
+   covariates <- model.matrix(~ -1 + as.factor(treatment.effect))
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=1,which.parameter.types=as.integer(c(0,1,0,0,1)),strata=as.integer(c(0,0,0,0,2)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =covariates,probe.type.levels=list(),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   ## PMMM ~ -1 + treatment + probes in treatment
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   treatment.effect <- c(1,1,2,2)
+ 
+   covariates <- model.matrix(~ -1 + as.factor(treatment.effect))
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,1,0,0,1)),strata=as.integer(c(0,0,0,0,2)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =covariates,probe.type.levels=list(),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+    ## PMMM ~ -1 + treatment + probe.effect in treatment
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   treatment.effect <- c(1,1,2,2)
+ 
+   covariates <- model.matrix(~ -1 + as.factor(treatment.effect))
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,1,0,1,0)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,-1,0)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =covariates,probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+    ## PMMM ~ -1+ probes
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+    ## PMMM ~ -1+ probes.type
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,1,0)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   ## PMMM ~ -1+ probes.type + probes
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,1,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=NULL,max.probe.type.trt.factor=0,probe.trt.factor=NULL,max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list(),probe.trt.levels=list())
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+     ## PMMM ~ -1+ probes.type + probes     with both within treatment factor
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,1,1)),strata=as.integer(c(0,0,0,2,2)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+     ## PMMM ~ -1+ probes.type + probes     with both within treatment factor and probes also within probe.type
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,1,1)),strata=as.integer(c(0,0,0,2,4)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+   ## PMMM ~ -1+ probes.type + probes     probe.types within treatment factor and probes also within probe.type
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,1,1)),strata=as.integer(c(0,0,0,2,3)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+  ## PMMM ~ -1+ probes.type + probes     probe.types within samples and probes also within probe.type
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,1,1)),strata=as.integer(c(0,0,0,1,3)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+ 
+   ## PMMM ~ intercept + probes.type + probes     probe.types within samples and probes also within probe.type
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(1,0,0,1,1)),strata=as.integer(c(0,0,0,1,3)),constraints=as.integer(c(0,0,0,-1,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+   
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+     ## PMMM ~ intercept + probes      probes also within probe.type
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(1,0,0,0,1)),strata=as.integer(c(0,0,0,0,3)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+   
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+      ## PMMM ~ -1+ probes      probes also within probe.type
+   output <- list(weights = TRUE, residuals = TRUE, varcov = c("none","chiplevel", "all"), resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,0,0,1)),strata=as.integer(c(0,0,0,0,3)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+   
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   # now play with varcov output
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+   
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+  # now play with varcov output and treatment
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+  treatment.effect <- c(1,1,2,2)
+ 
+   covariates <- model.matrix(~ -1 + as.factor(treatment.effect))
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,1,0,0,0)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =covariates,probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   
+ 
+   # now play with varcov output and an intercept
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(1,0,1,0,1)),strata=as.integer(c(0,0,0,0,0)),constraints=as.integer(c(0,0,-1,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=1,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+   
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+ 
+  # now play with varcov output and treatment and intercept
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+  treatment.effect <- c(1,1,2,2)
+ 
+   covariates <- matrix(model.matrix(~ as.factor(treatment.effect))[,2])
+   colnames(covariates) <- "trt_2"
+ 
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(1,1,0,0,0)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =covariates,probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   
+ 
+  # now play with varcov all option output and treatment and intercept
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+  treatment.effect <- c(1,1,2,2)
+    
+   covariates <- matrix(model.matrix(~ as.factor(treatment.effect))[,2])
+   colnames(covariates) <- "trt_2"
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(1,1,0,0,0)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,0)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =covariates,probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+  # now play with varcov all option output and samples and intercept
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(1,0,1,0,1)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,-1,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+        # now play with varcov all option output and samples and intercept, MM covarite
+     output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=1,response.variable=1,which.parameter.types=as.integer(c(1,0,1,0,1)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,-1,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+ 
+ 
+ 
+ 
+ 
+   ## now play with varcov all option output and samples and intercept, MM covariate and input chip weights
+   output <- verify.output.param(list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE))
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=c(1,1,0.5,0.5),weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=1,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   ## now play with varcov all option output and samples and intercept, MM covariate and input chip weights
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=runif(201800))
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=1,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+ 
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=c(rep(c(1,0.5),c(201800,201800))))
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   
+ 
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="cuberoot", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   
+ 
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log10", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   
+   R.model <- list(mmorpm.covariate=0,response.variable=0,which.parameter.types=as.integer(c(0,0,1,0,1)),strata=as.integer(c(0,0,0,2,0)),constraints=as.integer(c(0,0,0,0,-1)),probe.type.trt.factor=as.integer(c(0,0,1,1)),max.probe.type.trt.factor=1,probe.trt.factor=as.integer(c(0,0,1,1)),max.probe.trt.factor=0,chipcovariates =matrix(0,0,0),probe.type.levels=list("blah"=c("A","B")),probe.trt.levels=list("blah"=c("A","B")))
+ 
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+ }
> 
> 
> 
> if (test.PLM.modelmatrix){
+ 
+   library(affyPLM);data(Dilution)
+   
+   #PLM.designmatrix3(Dilution)
+   
+   #PLM.designmatrix3(Dilution,model=MM ~ PM -1 + samples +probe.type:probes)
+   
+   #PLM.designmatrix3(Dilution,model=MM ~ PM -1 + samples:probe.type + liver:probe.type:probes + liver:samples)
+   #PLM.designmatrix3(Dilution,model=MM ~ PM + samples:probe.type + liver:probe.type:probes + liver + samples)
+ 
+ 
+ 
+ 
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   #blah <- c(1,5,5,1)
+   #R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ probes + blah,constraint.type=c(probes="contr.sum"))
+   #R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ -1 + blah:probe.type)
+   #R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ -1 +probes:probe.type)
+   #R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ -1 +probes:blah)
+   #R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ -1 +probes:probe.type:blah)
+   #output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+ #  R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ samples,constraint.type=c(samples="contr.sum"))
+ #  R.model <-  PLM.designmatrix3(Dilution,model=PMMM ~ blah)
+ #   R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ -1 + samples)
+   #R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ probes + blah)
+   #R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ probes + blah)
+   #Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   library(affyPLM);data(Dilution)
+    output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ probe.type + probe.type:probes + samples)
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   library(affyPLM);data(Dilution)
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ samples:probe.type + probe.type:probes + samples)
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   
+  output <- list(weights = TRUE, residuals = TRUE, varcov ="chiplevel", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   blah <- c(1,2,2)
+   R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ blah:probe.type + probe.type:probes + samples)
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   blah <- c(1,2,2)
+   R.model <- PLM.designmatrix3(Dilution,model=PM ~ -1 + probes + MM + blah)
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+   
+   output <- list(weights = TRUE, residuals = TRUE, varcov ="all", resid.SE = TRUE)
+   modelparam <- list(trans.fn="log2", se.type = 4, psi.type = 0, psi.k =1.345,max.its = 20, init.method = "ls",weights.chip=NULL,weights.probe=NULL)
+   blah <- c(1,2,2)
+   R.model <- PLM.designmatrix3(Dilution,model=PM ~ -1 + probes + MM + samples)
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+ 
+ 
+ 
+ 
+ #test some of the verification functions
+ 
+ 
+   output <- verify.output.param()
+   modelparam <- verify.model.param(Dilution,PM ~ -1 + probes + MM + samples)
+   R.model <- PLM.designmatrix3(Dilution,model=PM ~ -1 + probes + MM + samples)
+  
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   ##verify.model.param(Dilution,PM ~ -1 + probes + MM + samples,model.param=list(weights.probe=rep(1,10)))
+ 
+    modelparam <- verify.model.param(Dilution,PMMM ~ -1 + probes + samples,model.param=list(weights.chip=c(1,2,3),weights.probe=rep(1,2400*2)))
+   R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ -1 + probes + samples)
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ 
+ 
+   
+  modelparam <- verify.model.param(Dilution,PM ~ -1 + probes + samples,model.param=list())
+   R.model <- PLM.designmatrix3(Dilution,model=PM ~ -1 + probes + samples)
+   Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   ## probes <- rep(1:16,3)
+   ##  chips <- rep(1:3,c(16,16,16))
+ 
+   ## library(MASS)
+   
+   ##fit <- rlm(log2(as.vector(pm(Dilution,"HG2188-HT2258_at"))) ~ -1 + as.factor(chips) + C(as.factor(probes),"contr.sum"))
+   
+ 
+ #test creating a PLMset based on the output from rlm_PLMset
+ 
+ ###  x <- new("PLMset")
+ ###  x@chip.coefs=Fitresults[[1]]
+ ###  x@probe.coefs= Fitresults[[2]]
+ ###  x@weights=Fitresults[[3]]
+ ###  x@se.chip.coefs=Fitresults[[4]]
+ ###  x@se.probe.coefs=Fitresults[[5]]
+ ###  x@exprs=Fitresults[[6]]
+ ###  x@se.exprs=Fitresults[[7]]
+ ###  x@residuals=Fitresults[[8]]
+ ###  x@residualSE=Fitresults[[9]]
+ ###  x@varcov = Fitresults[[10]]
+ ###  x@cdfName = Dilution@cdfName
+  ### x@phenoData = Dilution@phenoData
+  ### x@annotation = Dilution@annotation
+ ###  x@description = Dilution@description
+ ###  x@notes = Dilution@notes
+ ###  x@nrow= Dilution@nrow
+ ###  x@ncol= Dilution@ncol
+ ### x@model.description = c(x@model.description, list(R.model=R.model))
+ ###  image(x)
+ 
+ 
+ 
+ 
+ ###  data(Dilution)
+ ###  output <- verify.output.param()
+ ###  modelparam <- verify.model.param(Dilution,PMMM ~ -1 + probe.type:probes + samples + samples:probe.type,model.param=list())
+ ###  R.model <- PLM.designmatrix3(Dilution,model=PMMM ~ -1 + probe.type:probes + samples+ samples:probe.type)
+ ###  Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+ ###  output <- verify.output.param()
+ ###  modelparam <- verify.model.param(Dilution,MM ~ -1 + probes + samples,model.param=list())
+ ###  R.model <- PLM.designmatrix3(Dilution,model=MM ~ -1 + probes + samples)
+ ###  Fitresults <- .Call("rlm_PLMset",pm(Dilution),mm(Dilution),probeNames(Dilution),length(geneNames(Dilution)),R.model,output,modelparam)
+   
+   
+ 
+ ###  x <- new("PLMset")
+  ### x@chip.coefs=Fitresults[[1]]
+ ###  x@probe.coefs= Fitresults[[2]]
+ ###  x@weights=Fitresults[[3]]
+ ###  x@se.chip.coefs=Fitresults[[4]]
+ ###  x@se.probe.coefs=Fitresults[[5]]
+ ###  x@exprs=Fitresults[[6]]
+ ###  x@se.exprs=Fitresults[[7]]
+  ### x@residuals=Fitresults[[8]]
+ ###  x@residualSE=Fitresults[[9]]
+ ###  x@varcov = Fitresults[[10]]
+ ###  x@cdfName = Dilution@cdfName
+ ###  x@phenoData = Dilution@phenoData
+ ###  x@annotation = Dilution@annotation
+ ###  x@description = Dilution@description
+ ###  x@notes = Dilution@notes
+ ###  x@nrow= Dilution@nrow
+ ###  x@ncol= Dilution@ncol
+ ###  x@model.description = c(x@model.description, list(R.model=R.model))
+ ###  image(x)
+ ###  image(x,type="pos.resids")
+ ###  image(x,type="neg.resids")
+ ###  image(x,type="sign.resids")
+ 
+ ###  resid(x,"1091_at")
+ 
+ 
+ 
+ ###  weights(x,c("1091_at","1092_at"))
+ 
+ 
+ ###  image(x,type="resids",standardize=TRUE)
+ 
+ 
+ 
+ 
+   
+   
+ }
> 
> 
> 
> 
> 
> if (test.rlm){
+ 
+ 
+   library(affyPLM);data(Dilution)
+ 
+   y <- as.vector(log2(pm(Dilution)[1:16,]))
+ 
+   w <- runif(64)
+ 
+   probes <- rep(1:16,4)
+   samples <- rep(1:4,c(16,16,16,16))
+ 
+   x <- model.matrix( ~ -1 + as.factor(samples) + C(as.factor(probes),"contr.sum"))
+   x <- as.vector(x)
+ 
+   cols <- 19
+   rows <- 64
+   
+ 
+ #  rlm_wfit_R(double *x, double *y, double *w, int *rows, int *cols, double *out_beta, double *out_resids, double *out_weights)
+ 
+   fit1 <-.C("rlm_wfit_R",as.double(x),as.double(y),as.double(w),as.integer(rows),as.integer(cols),double(cols),double(rows),double(rows))
+ 
+ 
+   library(MASS)
+ 
+   fit2 <- rlm(y ~ -1 + as.factor(samples) + C(as.factor(probes),"contr.sum"),weights=w,wt.method="case")
+ 
+   if (any(abs(coef(fit2) - fit1[[6]]) > 10e-14)){
+     stop("Weighted RLM did not work")
+   }
+ 
+ 
+ 
+ 
+ 
+   y <- as.vector(log2(pm(Dilution,"1001_at")))
+   x <- as.vector(log2(mm(Dilution,"1001_at")))
+ 
+   rlm(y ~ -1 + x + as.factor(samples) + C(as.factor(probes),"contr.sum"))
+ 
+ 
+ 
+ 
+ 
+ 
+ 
+ 
+ 
+ 
+   
+ }
> 
> 
> 
> 
> proc.time()
   user  system elapsed 
   1.37    0.01    1.37 

affyPLM.Rcheck/tests_i386/PLM_tests.Rout


R version 4.0.2 (2020-06-22) -- "Taking Off Again"
Copyright (C) 2020 The R Foundation for Statistical Computing
Platform: i386-w64-mingw32/i386 (32-bit)

R is free software and comes with ABSOLUTELY NO WARRANTY.
You are welcome to redistribute it under certain conditions.
Type 'license()' or 'licence()' for distribution details.

R is a collaborative project with many contributors.
Type 'contributors()' for more information and
'citation()' on how to cite R or R packages in publications.

Type 'demo()' for some demos, 'help()' for on-line help, or
'help.start()' for an HTML browser interface to help.
Type 'q()' to quit R.

> do.all.tests <- FALSE
> if (do.all.tests){
+ 
+ # this file tests fitPLM and the PLMset object
+ 
+ library(affyPLM)
+ 
+ library(affydata)
+ data(Dilution)
+ 
+ 
+ Pset <- fitPLM(Dilution)
+ 
+ #check accessors for parameters and se
+ 
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ coefs.probe(Pset)[1:5]
+ se.probe(Pset)[1:5]
+ coefs.const(Pset)
+ se.const(Pset)
+ 
+ #accessors for weights and residuals
+ 
+ weights(Pset)[[1]][1:5,]
+ resid(Pset)[[1]][1:5,]
+ 
+ 
+ #test varcov
+ 
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,output.param=list(varcov="chiplevel"))
+ varcov(Pset)[1:3]
+ 
+ 
+ #test each of the possible weight functions
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,model.param=list(psi.type="Huber"))
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,model.param=list(psi.type="fair"))
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,model.param=list(psi.type="Cauchy"))
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,model.param=list(psi.type="Geman-McClure"))
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,model.param=list(psi.type="Welsch"))
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,model.param=list(psi.type="Tukey"))
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,model.param=list(psi.type="Andrews"))
+ 
+ # a larger example to do some testing of the graphical functions
+ 
+ data(Dilution)
+ 
+ Pset <- fitPLM(Dilution)
+ 
+ #testing the image capabilities
+ 
+ image(Pset,which=2)
+ image(Pset,which=2,type="resids")
+ image(Pset,which=2,type="pos.resids")
+ image(Pset,which=2,type="neg.resids")
+ image(Pset,which=2,type="resids",use.log=FALSE,add.legend=TRUE)
+ 
+ boxplot(Pset)
+ Mbox(Pset)
+ 
+ 
+ #test some non-default models functions
+ # no preprocessing for speed
+ 
+ Pset <- fitPLM(Dilution, PM ~ -1 + probes + liver,background=FALSE,normalize=FALSE)
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ 
+ 
+ Pset <- fitPLM(Dilution, PM ~ -1 + probes + liver + scanner,background=FALSE,normalize=FALSE)
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ 
+ #checking the constraints
+ Pset <- fitPLM(Dilution, PM ~ -1 + probes + liver + scanner,constraint.type=c(default="contr.sum"),background=FALSE,normalize=FALSE)
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ 
+ Pset <- fitPLM(Dilution, PM ~ -1 + liver + scanner,constraint.type=c(default="contr.sum"),background=FALSE,normalize=FALSE)
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ coefs.probe(Pset) # should be empty
+ 
+ Pset <- fitPLM(Dilution, PM ~ -1 + liver + scanner,constraint.type=c(probes="contr.treatment"),background=FALSE,normalize=FALSE)
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ coefs.probe(Pset) # should be empty
+ 
+ 
+ Pset <- fitPLM(Dilution, PM ~ -1 + probes + liver + scanner,constraint.type=c(probes="contr.treatment"),background=FALSE,normalize=FALSE)
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ coefs.probe(Pset)[1:16] 
+ 
+ 
+ scanner2 <- c(1,2,1,2) 
+ Pset <- fitPLM(Dilution, PM ~ -1 + probes + liver + scanner2,constraint.type=c(probes="contr.sum"),background=FALSE,normalize=FALSE)
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ coefs.probe(Pset)[1:16] 
+ 
+ #
+ #Pset <- fitPLM(Dilution,model=PM~-1+probes+scanner,normalize=FALSE,background=FALSE,model.param=list(se.type=3))
+ #se(Pset)[1:10,]
+ 
+ #check that fitPLM rlm agrees with threestep rlm and threestepPLM rlm
+ 
+ 
+ Pset <- fitPLM(Dilution)
+ eset <- threestep(Dilution,summary.method="rlm")
+ Pset2 <- threestepPLM(Dilution,summary.method="rlm")
+ 
+ if (any(abs(coefs(Pset) - exprs(eset)) > 1e-14)){
+   stop("no agreement between fitPLM and threestep")
+ }
+ 
+ if (any(abs(coefs(Pset) - coefs(Pset2)) > 1e-14)){
+   stop("no agreement between fitPLM and threestep")
+ }
+ }
> 
> proc.time()
   user  system elapsed 
   0.15    0.04    0.18 

affyPLM.Rcheck/tests_x64/PLM_tests.Rout


R version 4.0.2 (2020-06-22) -- "Taking Off Again"
Copyright (C) 2020 The R Foundation for Statistical Computing
Platform: x86_64-w64-mingw32/x64 (64-bit)

R is free software and comes with ABSOLUTELY NO WARRANTY.
You are welcome to redistribute it under certain conditions.
Type 'license()' or 'licence()' for distribution details.

R is a collaborative project with many contributors.
Type 'contributors()' for more information and
'citation()' on how to cite R or R packages in publications.

Type 'demo()' for some demos, 'help()' for on-line help, or
'help.start()' for an HTML browser interface to help.
Type 'q()' to quit R.

> do.all.tests <- FALSE
> if (do.all.tests){
+ 
+ # this file tests fitPLM and the PLMset object
+ 
+ library(affyPLM)
+ 
+ library(affydata)
+ data(Dilution)
+ 
+ 
+ Pset <- fitPLM(Dilution)
+ 
+ #check accessors for parameters and se
+ 
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ coefs.probe(Pset)[1:5]
+ se.probe(Pset)[1:5]
+ coefs.const(Pset)
+ se.const(Pset)
+ 
+ #accessors for weights and residuals
+ 
+ weights(Pset)[[1]][1:5,]
+ resid(Pset)[[1]][1:5,]
+ 
+ 
+ #test varcov
+ 
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,output.param=list(varcov="chiplevel"))
+ varcov(Pset)[1:3]
+ 
+ 
+ #test each of the possible weight functions
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,model.param=list(psi.type="Huber"))
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,model.param=list(psi.type="fair"))
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,model.param=list(psi.type="Cauchy"))
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,model.param=list(psi.type="Geman-McClure"))
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,model.param=list(psi.type="Welsch"))
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,model.param=list(psi.type="Tukey"))
+ Pset <- fitPLM(Dilution,background=FALSE,normalize=FALSE,model.param=list(psi.type="Andrews"))
+ 
+ # a larger example to do some testing of the graphical functions
+ 
+ data(Dilution)
+ 
+ Pset <- fitPLM(Dilution)
+ 
+ #testing the image capabilities
+ 
+ image(Pset,which=2)
+ image(Pset,which=2,type="resids")
+ image(Pset,which=2,type="pos.resids")
+ image(Pset,which=2,type="neg.resids")
+ image(Pset,which=2,type="resids",use.log=FALSE,add.legend=TRUE)
+ 
+ boxplot(Pset)
+ Mbox(Pset)
+ 
+ 
+ #test some non-default models functions
+ # no preprocessing for speed
+ 
+ Pset <- fitPLM(Dilution, PM ~ -1 + probes + liver,background=FALSE,normalize=FALSE)
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ 
+ 
+ Pset <- fitPLM(Dilution, PM ~ -1 + probes + liver + scanner,background=FALSE,normalize=FALSE)
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ 
+ #checking the constraints
+ Pset <- fitPLM(Dilution, PM ~ -1 + probes + liver + scanner,constraint.type=c(default="contr.sum"),background=FALSE,normalize=FALSE)
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ 
+ Pset <- fitPLM(Dilution, PM ~ -1 + liver + scanner,constraint.type=c(default="contr.sum"),background=FALSE,normalize=FALSE)
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ coefs.probe(Pset) # should be empty
+ 
+ Pset <- fitPLM(Dilution, PM ~ -1 + liver + scanner,constraint.type=c(probes="contr.treatment"),background=FALSE,normalize=FALSE)
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ coefs.probe(Pset) # should be empty
+ 
+ 
+ Pset <- fitPLM(Dilution, PM ~ -1 + probes + liver + scanner,constraint.type=c(probes="contr.treatment"),background=FALSE,normalize=FALSE)
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ coefs.probe(Pset)[1:16] 
+ 
+ 
+ scanner2 <- c(1,2,1,2) 
+ Pset <- fitPLM(Dilution, PM ~ -1 + probes + liver + scanner2,constraint.type=c(probes="contr.sum"),background=FALSE,normalize=FALSE)
+ coefs(Pset)[1:5,]
+ se(Pset)[1:5,]
+ coefs.probe(Pset)[1:16] 
+ 
+ #
+ #Pset <- fitPLM(Dilution,model=PM~-1+probes+scanner,normalize=FALSE,background=FALSE,model.param=list(se.type=3))
+ #se(Pset)[1:10,]
+ 
+ #check that fitPLM rlm agrees with threestep rlm and threestepPLM rlm
+ 
+ 
+ Pset <- fitPLM(Dilution)
+ eset <- threestep(Dilution,summary.method="rlm")
+ Pset2 <- threestepPLM(Dilution,summary.method="rlm")
+ 
+ if (any(abs(coefs(Pset) - exprs(eset)) > 1e-14)){
+   stop("no agreement between fitPLM and threestep")
+ }
+ 
+ if (any(abs(coefs(Pset) - coefs(Pset2)) > 1e-14)){
+   stop("no agreement between fitPLM and threestep")
+ }
+ }
> 
> proc.time()
   user  system elapsed 
    0.2     0.0     0.2 

affyPLM.Rcheck/tests_i386/preprocess_tests.Rout


R version 4.0.2 (2020-06-22) -- "Taking Off Again"
Copyright (C) 2020 The R Foundation for Statistical Computing
Platform: i386-w64-mingw32/i386 (32-bit)

R is free software and comes with ABSOLUTELY NO WARRANTY.
You are welcome to redistribute it under certain conditions.
Type 'license()' or 'licence()' for distribution details.

R is a collaborative project with many contributors.
Type 'contributors()' for more information and
'citation()' on how to cite R or R packages in publications.

Type 'demo()' for some demos, 'help()' for on-line help, or
'help.start()' for an HTML browser interface to help.
Type 'q()' to quit R.

> #test the preprocessing functionality
> 
> library(affyPLM)
Loading required package: BiocGenerics
Loading required package: parallel

Attaching package: 'BiocGenerics'

The following objects are masked from 'package:parallel':

    clusterApply, clusterApplyLB, clusterCall, clusterEvalQ,
    clusterExport, clusterMap, parApply, parCapply, parLapply,
    parLapplyLB, parRapply, parSapply, parSapplyLB

The following objects are masked from 'package:stats':

    IQR, mad, sd, var, xtabs

The following objects are masked from 'package:base':

    Filter, Find, Map, Position, Reduce, anyDuplicated, append,
    as.data.frame, basename, cbind, colnames, dirname, do.call,
    duplicated, eval, evalq, get, grep, grepl, intersect, is.unsorted,
    lapply, mapply, match, mget, order, paste, pmax, pmax.int, pmin,
    pmin.int, rank, rbind, rownames, sapply, setdiff, sort, table,
    tapply, union, unique, unsplit, which.max, which.min

Loading required package: affy
Loading required package: Biobase
Welcome to Bioconductor

    Vignettes contain introductory material; view with
    'browseVignettes()'. To cite Bioconductor, see
    'citation("Biobase")', and for packages 'citation("pkgname")'.

Loading required package: gcrma
Loading required package: preprocessCore
> library(affydata)
     Package    LibPath                                      Item      
[1,] "affydata" "C:/Users/biocbuild/bbs-3.12-bioc/R/library" "Dilution"
     Title                        
[1,] "AffyBatch instance Dilution"
> data(Dilution)
> 
> 
> ### NO LONGER SUPPORTED eset <- threestep(Dilution,background.method="RMA.1")
> eset <- threestep(Dilution,background.method="RMA.2")

Warning messages:
1: replacing previous import 'AnnotationDbi::tail' by 'utils::tail' when loading 'hgu95av2cdf' 
2: replacing previous import 'AnnotationDbi::head' by 'utils::head' when loading 'hgu95av2cdf' 
> eset <- threestep(Dilution,background.method="IdealMM")
> eset <- threestep(Dilution,background.method="MAS")
> eset <- threestep(Dilution,background.method="MASIM")
> eset <- threestep(Dilution,background.method="LESN2")
> eset <- threestep(Dilution,background.method="LESN1")
> eset <- threestep(Dilution,background.method="LESN0")
> 
> eset <- threestep(Dilution,normalize.method="quantile",background=FALSE)
> eset <- threestep(Dilution,normalize.method="quantile.probeset",background=FALSE)
> eset <- threestep(Dilution,normalize.method="scaling",background=FALSE)
> 
> 
> 
> proc.time()
   user  system elapsed 
  20.95    0.64   21.57 

affyPLM.Rcheck/tests_x64/preprocess_tests.Rout


R version 4.0.2 (2020-06-22) -- "Taking Off Again"
Copyright (C) 2020 The R Foundation for Statistical Computing
Platform: x86_64-w64-mingw32/x64 (64-bit)

R is free software and comes with ABSOLUTELY NO WARRANTY.
You are welcome to redistribute it under certain conditions.
Type 'license()' or 'licence()' for distribution details.

R is a collaborative project with many contributors.
Type 'contributors()' for more information and
'citation()' on how to cite R or R packages in publications.

Type 'demo()' for some demos, 'help()' for on-line help, or
'help.start()' for an HTML browser interface to help.
Type 'q()' to quit R.

> #test the preprocessing functionality
> 
> library(affyPLM)
Loading required package: BiocGenerics
Loading required package: parallel

Attaching package: 'BiocGenerics'

The following objects are masked from 'package:parallel':

    clusterApply, clusterApplyLB, clusterCall, clusterEvalQ,
    clusterExport, clusterMap, parApply, parCapply, parLapply,
    parLapplyLB, parRapply, parSapply, parSapplyLB

The following objects are masked from 'package:stats':

    IQR, mad, sd, var, xtabs

The following objects are masked from 'package:base':

    Filter, Find, Map, Position, Reduce, anyDuplicated, append,
    as.data.frame, basename, cbind, colnames, dirname, do.call,
    duplicated, eval, evalq, get, grep, grepl, intersect, is.unsorted,
    lapply, mapply, match, mget, order, paste, pmax, pmax.int, pmin,
    pmin.int, rank, rbind, rownames, sapply, setdiff, sort, table,
    tapply, union, unique, unsplit, which.max, which.min

Loading required package: affy
Loading required package: Biobase
Welcome to Bioconductor

    Vignettes contain introductory material; view with
    'browseVignettes()'. To cite Bioconductor, see
    'citation("Biobase")', and for packages 'citation("pkgname")'.

Loading required package: gcrma
Loading required package: preprocessCore
> library(affydata)
     Package    LibPath                                      Item      
[1,] "affydata" "C:/Users/biocbuild/bbs-3.12-bioc/R/library" "Dilution"
     Title                        
[1,] "AffyBatch instance Dilution"
> data(Dilution)
> 
> 
> ### NO LONGER SUPPORTED eset <- threestep(Dilution,background.method="RMA.1")
> eset <- threestep(Dilution,background.method="RMA.2")

Warning messages:
1: replacing previous import 'AnnotationDbi::tail' by 'utils::tail' when loading 'hgu95av2cdf' 
2: replacing previous import 'AnnotationDbi::head' by 'utils::head' when loading 'hgu95av2cdf' 
> eset <- threestep(Dilution,background.method="IdealMM")
> eset <- threestep(Dilution,background.method="MAS")
> eset <- threestep(Dilution,background.method="MASIM")
> eset <- threestep(Dilution,background.method="LESN2")
> eset <- threestep(Dilution,background.method="LESN1")
> eset <- threestep(Dilution,background.method="LESN0")
> 
> eset <- threestep(Dilution,normalize.method="quantile",background=FALSE)
> eset <- threestep(Dilution,normalize.method="quantile.probeset",background=FALSE)
> eset <- threestep(Dilution,normalize.method="scaling",background=FALSE)
> 
> 
> 
> proc.time()
   user  system elapsed 
  20.60    0.53   21.12 

affyPLM.Rcheck/tests_i386/threestepPLM_tests.Rout


R version 4.0.2 (2020-06-22) -- "Taking Off Again"
Copyright (C) 2020 The R Foundation for Statistical Computing
Platform: i386-w64-mingw32/i386 (32-bit)

R is free software and comes with ABSOLUTELY NO WARRANTY.
You are welcome to redistribute it under certain conditions.
Type 'license()' or 'licence()' for distribution details.

R is a collaborative project with many contributors.
Type 'contributors()' for more information and
'citation()' on how to cite R or R packages in publications.

Type 'demo()' for some demos, 'help()' for on-line help, or
'help.start()' for an HTML browser interface to help.
Type 'q()' to quit R.

> if (.Platform$OS.type != "windows"){
+ library(affyPLM)
+ 
+ # test threestep and threestepPLM to see if they agree
+ 
+ 
+ check.coefs <- function(Pset,Pset2){
+   if (any(abs(coefs(Pset) - exprs(Pset2)) > 1e-14)){
+     stop("No agreement between threestepPLM and threestep in coefs")
+   }	
+ }
+ 
+ check.resids <- function(Pset,Pset2){
+   if (any(resid(Pset) != resid(Pset2))){
+     stop("No agreement between threestepPLM and rmaPLM/threestep in residuals")
+   }
+ }
+ 
+ 
+ library(affydata)
+ data(Dilution)
+ 
+ Pset <- threestepPLM(Dilution)
+ Pset2 <- threestep(Dilution)
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="tukey.biweight")
+ Pset2 <- threestep(Dilution,summary.method="tukey.biweight")
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="average.log")
+ Pset2 <- threestep(Dilution,summary.method="average.log")
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="rlm")
+ Pset2 <- threestep(Dilution,summary.method="rlm")
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="log.average")
+ Pset2 <- threestep(Dilution,summary.method="log.average")
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="log.median")
+ Pset2 <- threestep(Dilution,summary.method="log.median")
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="median.log")
+ Pset2 <- threestep(Dilution,summary.method="median.log")
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="log.2nd.largest")
+ Pset2 <- threestep(Dilution,summary.method="log.2nd.largest")
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="lm")
+ Pset2 <- threestep(Dilution,summary.method="lm")
+ check.coefs(Pset,Pset2)
+ 
+ #check if threestepPLM agrees with rmaPLM
+ Pset <- threestepPLM(Dilution)
+ Pset2 <- rmaPLM(Dilution)
+ 
+ if (any(coefs(Pset) != coefs(Pset2))){
+    stop("No agreement between threestepPLM and rmaPLM in coefs")
+ }
+ 
+ 
+ if (any(resid(Pset)[[1]] != resid(Pset2)[[1]])){
+    stop("No agreement between threestepPLM and rmaPLM in residuals")
+ }
+ }
> 
> proc.time()
   user  system elapsed 
   0.25    0.06    0.29 

affyPLM.Rcheck/tests_x64/threestepPLM_tests.Rout


R version 4.0.2 (2020-06-22) -- "Taking Off Again"
Copyright (C) 2020 The R Foundation for Statistical Computing
Platform: x86_64-w64-mingw32/x64 (64-bit)

R is free software and comes with ABSOLUTELY NO WARRANTY.
You are welcome to redistribute it under certain conditions.
Type 'license()' or 'licence()' for distribution details.

R is a collaborative project with many contributors.
Type 'contributors()' for more information and
'citation()' on how to cite R or R packages in publications.

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> if (.Platform$OS.type != "windows"){
+ library(affyPLM)
+ 
+ # test threestep and threestepPLM to see if they agree
+ 
+ 
+ check.coefs <- function(Pset,Pset2){
+   if (any(abs(coefs(Pset) - exprs(Pset2)) > 1e-14)){
+     stop("No agreement between threestepPLM and threestep in coefs")
+   }	
+ }
+ 
+ check.resids <- function(Pset,Pset2){
+   if (any(resid(Pset) != resid(Pset2))){
+     stop("No agreement between threestepPLM and rmaPLM/threestep in residuals")
+   }
+ }
+ 
+ 
+ library(affydata)
+ data(Dilution)
+ 
+ Pset <- threestepPLM(Dilution)
+ Pset2 <- threestep(Dilution)
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="tukey.biweight")
+ Pset2 <- threestep(Dilution,summary.method="tukey.biweight")
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="average.log")
+ Pset2 <- threestep(Dilution,summary.method="average.log")
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="rlm")
+ Pset2 <- threestep(Dilution,summary.method="rlm")
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="log.average")
+ Pset2 <- threestep(Dilution,summary.method="log.average")
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="log.median")
+ Pset2 <- threestep(Dilution,summary.method="log.median")
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="median.log")
+ Pset2 <- threestep(Dilution,summary.method="median.log")
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="log.2nd.largest")
+ Pset2 <- threestep(Dilution,summary.method="log.2nd.largest")
+ check.coefs(Pset,Pset2)
+ 
+ Pset <- threestepPLM(Dilution,summary.method="lm")
+ Pset2 <- threestep(Dilution,summary.method="lm")
+ check.coefs(Pset,Pset2)
+ 
+ #check if threestepPLM agrees with rmaPLM
+ Pset <- threestepPLM(Dilution)
+ Pset2 <- rmaPLM(Dilution)
+ 
+ if (any(coefs(Pset) != coefs(Pset2))){
+    stop("No agreement between threestepPLM and rmaPLM in coefs")
+ }
+ 
+ 
+ if (any(resid(Pset)[[1]] != resid(Pset2)[[1]])){
+    stop("No agreement between threestepPLM and rmaPLM in residuals")
+ }
+ }
> 
> proc.time()
   user  system elapsed 
   0.15    0.03    0.17 

Example timings

affyPLM.Rcheck/examples_i386/affyPLM-Ex.timings

nameusersystemelapsed
PLMset2exprSet5.800.115.91
bg.correct.LESN1.240.091.33
fitPLM12.19 0.3312.52
normalize.exprSet0.910.001.31
normalize.scaling1.730.011.75
preprocess2.180.082.26
rmaPLM0.30.00.3
threestep19.41 0.2119.61
threestepPLM0.280.010.45

affyPLM.Rcheck/examples_x64/affyPLM-Ex.timings

nameusersystemelapsed
PLMset2exprSet5.710.065.77
bg.correct.LESN1.510.051.56
fitPLM12.22 0.4612.69
normalize.exprSet0.890.000.89
normalize.scaling1.330.071.39
preprocess2.140.032.17
rmaPLM0.280.000.28
threestep19.31 0.2019.52
threestepPLM0.410.020.42