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timescape

This is the development version of timescape; for the stable release version, see timescape.

Patient Clonal Timescapes


Bioconductor version: Development (3.19)

TimeScape is an automated tool for navigating temporal clonal evolution data. The key attributes of this implementation involve the enumeration of clones, their evolutionary relationships and their shifting dynamics over time. TimeScape requires two inputs: (i) the clonal phylogeny and (ii) the clonal prevalences. Optionally, TimeScape accepts a data table of targeted mutations observed in each clone and their allele prevalences over time. The output is the TimeScape plot showing clonal prevalence vertically, time horizontally, and the plot height optionally encoding tumour volume during tumour-shrinking events. At each sampling time point (denoted by a faint white line), the height of each clone accurately reflects its proportionate prevalence. These prevalences form the anchors for bezier curves that visually represent the dynamic transitions between time points.

Author: Maia Smith [aut, cre]

Maintainer: Maia Smith <maiaannesmith at gmail.com>

Citation (from within R, enter citation("timescape")):

Installation

To install this package, start R (version "4.4") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

# The following initializes usage of Bioc devel
BiocManager::install(version='devel')

BiocManager::install("timescape")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("timescape")
TimeScape vignette HTML R Script
Reference Manual PDF

Details

biocViews BiomedicalInformatics, Software, Visualization
Version 1.27.0
In Bioconductor since BioC 3.5 (R-3.4) (7 years)
License GPL-3
Depends R (>= 3.3)
Imports htmlwidgets (>= 0.5), jsonlite (>= 0.9.19), stringr (>= 1.0.0), dplyr (>= 0.4.3), gtools (>= 3.5.0)
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package timescape_1.27.0.tar.gz
Windows Binary timescape_1.27.0.zip
macOS Binary (x86_64) timescape_1.27.0.tgz
macOS Binary (arm64)
Source Repository git clone https://git.bioconductor.org/packages/timescape
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/timescape
Bioc Package Browser https://code.bioconductor.org/browse/timescape/
Package Short Url https://bioconductor.org/packages/timescape/
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