Registration Open for Bioc2024 July 24-26


This is the development version of lionessR; for the stable release version, see lionessR.

Modeling networks for individual samples using LIONESS

Bioconductor version: Development (3.20)

LIONESS, or Linear Interpolation to Obtain Network Estimates for Single Samples, can be used to reconstruct single-sample networks ( This code implements the LIONESS equation in the lioness function in R to reconstruct single-sample networks. The default network reconstruction method we use is based on Pearson correlation. However, lionessR can run on any network reconstruction algorithms that returns a complete, weighted adjacency matrix. lionessR works for both unipartite and bipartite networks.

Author: Marieke Lydia Kuijjer [aut] , Ping-Han Hsieh [cre]

Maintainer: Ping-Han Hsieh <dn070017 at>

Citation (from within R, enter citation("lionessR")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))

# The following initializes usage of Bioc devel


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

lionessR HTML R Script
Reference Manual PDF


biocViews GeneExpression, Network, NetworkInference, Software
Version 1.19.0
In Bioconductor since BioC 3.10 (R-3.6) (4.5 years)
License MIT + file LICENSE
Depends R (>= 3.6.0)
Imports stats, SummarizedExperiment, S4Vectors
System Requirements
Bug Reports
See More
Suggests knitr, rmarkdown, igraph, reshape2, limma
Linking To
Depends On Me
Imports Me
Suggests Me
Links To Me
Build Report Build Report

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package lionessR_1.19.0.tar.gz
Windows Binary (64-bit only)
macOS Binary (x86_64) lionessR_1.19.0.tgz
macOS Binary (arm64) lionessR_1.19.0.tgz
Source Repository git clone
Source Repository (Developer Access) git clone
Bioc Package Browser
Package Short Url
Package Downloads Report Download Stats