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This is the development version of RolDE; for the stable release version, see RolDE.

RolDE: Robust longitudinal Differential Expression

Bioconductor version: Development (3.20)

RolDE detects longitudinal differential expression between two conditions in noisy high-troughput data. Suitable even for data with a moderate amount of missing values.RolDE is a composite method, consisting of three independent modules with different approaches to detecting longitudinal differential expression. The combination of these diverse modules allows RolDE to robustly detect varying differences in longitudinal trends and expression levels in diverse data types and experimental settings.

Author: Tommi Valikangas [aut], Medical Bioinformatics Centre [cre]

Maintainer: Medical Bioinformatics Centre <mbc at>

Citation (from within R, enter citation("RolDE")):


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biocViews DifferentialExpression, Proteomics, Regression, Software, StatisticalMethod, TimeCourse
Version 1.9.0
In Bioconductor since BioC 3.15 (R-4.2) (2 years)
License GPL-3
Depends R (>= 4.2.0)
Imports stats, methods, ROTS, matrixStats, foreach, parallel, doParallel, doRNG, rngtools, SummarizedExperiment, nlme, qvalue, grDevices, graphics, utils
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Source Package RolDE_1.9.0.tar.gz
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