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Testing Groups of Covariates/Features for Association with a Response Variable, with Applications to Gene Set Testing

Bioconductor version: Release (3.18)

The global test tests groups of covariates (or features) for association with a response variable. This package implements the test with diagnostic plots and multiple testing utilities, along with several functions to facilitate the use of this test for gene set testing of GO and KEGG terms.

Author: Jelle Goeman and Jan Oosting, with contributions by Livio Finos, Aldo Solari, Dominic Edelmann

Maintainer: Jelle Goeman <j.j.goeman at lumc.nl>

Citation (from within R, enter citation("globaltest")):


To install this package, start R (version "4.3") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

Global Test PDF R Script
Reference Manual PDF


biocViews Bioinformatics, DifferentialExpression, GO, Microarray, OneChannel, Pathways, Software
Version 5.56.0
In Bioconductor since BioC 1.6 (R-2.1) or earlier (> 19 years)
License GPL (>= 2)
Depends methods, survival
Imports Biobase, AnnotationDbi, annotate, graphics
System Requirements
See More
Suggests vsn, golubEsets, KEGGREST, hu6800.db, Rgraphviz, GO.db, lungExpression, org.Hs.eg.db, GSEABase, penalized, gss, MASS, boot, rpart, mstate
Linking To
Depends On Me GlobalAncova
Imports Me BiSeq, ChAMP, EGSEA, SIM
Suggests Me topGO
Links To Me
Build Report Build Report

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package globaltest_5.56.0.tar.gz
Windows Binary globaltest_5.56.0.zip
macOS Binary (x86_64) globaltest_5.56.0.tgz
macOS Binary (arm64)
Source Repository git clone https://git.bioconductor.org/packages/globaltest
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/globaltest
Bioc Package Browser https://code.bioconductor.org/browse/globaltest/
Package Short Url https://bioconductor.org/packages/globaltest/
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