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Bisulfite-seq OutlieR mEthylation At singLe-sIte reSolution

Bioconductor version: Release (3.19)

Borealis is an R library performing outlier analysis for count-based bisulfite sequencing data. It detectes outlier methylated CpG sites from bisulfite sequencing (BS-seq). The core of Borealis is modeling Beta-Binomial distributions. This can be useful for rare disease diagnoses.

Author: Garrett Jenkinson [aut, cre]

Maintainer: Garrett Jenkinson <gargar934 at>

Citation (from within R, enter citation("borealis")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

Borealis outlier methylation detection HTML R Script
Reference Manual PDF


biocViews Coverage, DNAMethylation, DifferentialMethylation, Sequencing, Software
Version 1.8.0
In Bioconductor since BioC 3.15 (R-4.2) (2 years)
License GPL-3
Depends R (>= 4.2.0), Biobase
Imports doParallel, snow, purrr, plyr, foreach, gamlss, gamlss.dist, bsseq, methods, DSS, R.utils, utils, stats, ggplot2, cowplot, dplyr, rlang, GenomicRanges
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Suggests BiocStyle, knitr, rmarkdown, RUnit, BiocGenerics, annotatr, tidyr, TxDb.Hsapiens.UCSC.hg19.knownGene,
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Follow Installation instructions to use this package in your R session.

Source Package borealis_1.8.0.tar.gz
Windows Binary (64-bit only)
macOS Binary (x86_64) borealis_1.8.0.tgz
macOS Binary (arm64) borealis_1.8.0.tgz
Source Repository git clone
Source Repository (Developer Access) git clone
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