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Efficient Manipulation of Modified Oligonucleotide Sequences

Bioconductor version: Release (3.18)

The XNAString package allows for description of base sequences and associated chemical modifications in a single object. XNAString is able to capture single stranded, as well as double stranded molecules. Chemical modifications are represented as independent strings associated with different features of the molecules (base sequence, sugar sequence, backbone sequence, modifications) and can be read or written to a HELM notation. It also enables secondary structure prediction using RNAfold from ViennaRNA. XNAString is designed to be efficient representation of nucleic-acid based therapeutics, therefore it stores information about target sequences and provides interface for matching and alignment functions from Biostrings package.

Author: Anna Górska [aut], Marianna Plucinska [aut, cre], Lykke Pedersen [aut], Lukasz Kielpinski [aut], Disa Tehler [aut], Peter H. Hagedorn [aut]

Maintainer: Marianna Plucinska <marianna.plucinska at roche.com>

Citation (from within R, enter citation("XNAString")):


To install this package, start R (version "4.3") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

XNAString classes and functionalities HTML R Script
Reference Manual PDF


biocViews Alignment, Genetics, SequenceMatching, Sequencing, Software
Version 1.10.0
In Bioconductor since BioC 3.13 (R-4.1) (3 years)
License GPL-2
Depends R (>= 4.1)
Imports utils, Biostrings, BSgenome, data.table, GenomicRanges, IRanges, methods, Rcpp, stringi, S4Vectors, future.apply, stringr, formattable, stats
System Requirements
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Suggests BiocStyle, knitr, rmarkdown, markdown, testthat, BSgenome.Hsapiens.UCSC.hg38, pander
Linking To Rcpp
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package XNAString_1.10.0.tar.gz
Windows Binary XNAString_1.10.0.zip
macOS Binary (x86_64) XNAString_1.10.0.tgz
macOS Binary (arm64) XNAString_1.10.0.tgz
Source Repository git clone https://git.bioconductor.org/packages/XNAString
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/XNAString
Bioc Package Browser https://code.bioconductor.org/browse/XNAString/
Package Short Url https://bioconductor.org/packages/XNAString/
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