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NGS Read Simulator for FFPE Tissue

Bioconductor version: Release (3.18)

The NGS (Next-Generation Sequencing) reads from FFPE (Formalin-Fixed Paraffin-Embedded) samples contain numerous artifact chimeric reads (ACRS), which can lead to false positive structural variant calls. These ACRs are derived from the combination of two single-stranded DNA (ss-DNA) fragments with short reverse complementary regions (SRCRs). This package simulates these artifact chimeric reads as well as normal reads for FFPE samples on the whole genome / several chromosomes / large regions.

Author: Lanying Wei [aut, cre]

Maintainer: Lanying Wei <lanying.wei at uni-muenster.de>

Citation (from within R, enter citation("SimFFPE")):


To install this package, start R (version "4.3") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

An introduction to SimFFPE PDF R Script
Reference Manual PDF


biocViews Alignment, DataImport, MultipleComparison, SequenceMatching, Sequencing, Software
Version 1.14.0
In Bioconductor since BioC 3.11 (R-4.0) (4 years)
License LGPL-3
Depends Biostrings
Imports dplyr, foreach, doParallel, truncnorm, GenomicRanges, IRanges, Rsamtools, parallel, graphics, stats, utils, methods
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package SimFFPE_1.14.0.tar.gz
Windows Binary SimFFPE_1.14.0.zip (64-bit only)
macOS Binary (x86_64) SimFFPE_1.14.0.tgz
macOS Binary (arm64) SimFFPE_1.14.0.tgz
Source Repository git clone https://git.bioconductor.org/packages/SimFFPE
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/SimFFPE
Bioc Package Browser https://code.bioconductor.org/browse/SimFFPE/
Package Short Url https://bioconductor.org/packages/SimFFPE/
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