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A compilation of metadata from NCBI SRA and tools

Bioconductor version: Release (3.19)

The Sequence Read Archive (SRA) is the largest public repository of sequencing data from the next generation of sequencing platforms including Roche 454 GS System, Illumina Genome Analyzer, Applied Biosystems SOLiD System, Helicos Heliscope, and others. However, finding data of interest can be challenging using current tools. SRAdb is an attempt to make access to the metadata associated with submission, study, sample, experiment and run much more feasible. This is accomplished by parsing all the NCBI SRA metadata into a SQLite database that can be stored and queried locally. Fulltext search in the package make querying metadata very flexible and powerful. fastq and sra files can be downloaded for doing alignment locally. Beside ftp protocol, the SRAdb has funcitons supporting fastp protocol (ascp from Aspera Connect) for faster downloading large data files over long distance. The SQLite database is updated regularly as new data is added to SRA and can be downloaded at will for the most up-to-date metadata.

Author: Jack Zhu and Sean Davis

Maintainer: Jack Zhu <zhujack at>

Citation (from within R, enter citation("SRAdb")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

Using SRAdb to Query the Sequence Read Archive PDF R Script
Reference Manual PDF


biocViews DataImport, Infrastructure, Sequencing, Software
Version 1.66.0
In Bioconductor since BioC 2.6 (R-2.11) (14.5 years)
License Artistic-2.0
Depends RSQLite, graph, RCurl
Imports GEOquery
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Follow Installation instructions to use this package in your R session.

Source Package SRAdb_1.66.0.tar.gz
Windows Binary
macOS Binary (x86_64) SRAdb_1.66.0.tgz
macOS Binary (arm64) SRAdb_1.66.0.tgz
Source Repository git clone
Source Repository (Developer Access) git clone
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