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This package is deprecated. It will probably be removed from Bioconductor. Please refer to the package end-of-life guidelines for more information.

This package is for version 3.18 of Bioconductor. This package has been removed from Bioconductor. For the last stable, up-to-date release version, see SEPIRA.

Systems EPigenomics Inference of Regulatory Activity

Bioconductor version: Release (3.18)

SEPIRA (Systems EPigenomics Inference of Regulatory Activity) is an algorithm that infers sample-specific transcription factor activity from the genome-wide expression or DNA methylation profile of the sample.

Author: Yuting Chen [aut, cre], Andrew Teschendorff [aut]

Maintainer: Yuting Chen <cytwarmmay at>

Citation (from within R, enter citation("SEPIRA")):


To install this package, start R (version "4.3") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

Introduction to `SEPIRA` HTML R Script
Reference Manual PDF


biocViews GeneExpression, GeneRegulation, GeneTarget, Network, NetworkInference, Software, Transcription
Version 1.22.0
In Bioconductor since BioC 3.7 (R-3.5) (6 years)
License GPL-3
Depends R (>= 3.5.0)
Imports limma(>= 3.32.5), corpcor (>= 1.6.9), parallel (>= 3.3.1), stats
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Source Package SEPIRA_1.22.0.tar.gz
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