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A multi-tissue transcriptional age calculator

Bioconductor version: Release (3.18)

It has been shown that both DNA methylation and RNA transcription are linked to chronological age and age related diseases. Several estimators have been developed to predict human aging from DNA level and RNA level. Most of the human transcriptional age predictor are based on microarray data and limited to only a few tissues. To date, transcriptional studies on aging using RNASeq data from different human tissues is limited. The aim of this package is to provide a tool for across-tissue and tissue-specific transcriptional age calculation based on GTEx RNASeq data.

Author: Xu Ren [aut, cre], Pei Fen Kuan [aut]

Maintainer: Xu Ren <xuren2120 at gmail.com>

Citation (from within R, enter citation("RNAAgeCalc")):


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if (!require("BiocManager", quietly = TRUE))


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To view documentation for the version of this package installed in your system, start R and enter:

RNAAgeCalc HTML R Script
Reference Manual PDF


biocViews GeneExpression, RNASeq, Software
Version 1.14.0
In Bioconductor since BioC 3.11 (R-4.0) (4 years)
License GPL-2
Depends R (>= 3.6)
Imports ggplot2, recount, impute, AnnotationDbi, org.Hs.eg.db, stats, SummarizedExperiment, methods
System Requirements
URL https://github.com/reese3928/RNAAgeCalc
Bug Reports https://github.com/reese3928/RNAAgeCalc/issues
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Follow Installation instructions to use this package in your R session.

Source Package RNAAgeCalc_1.14.0.tar.gz
Windows Binary RNAAgeCalc_1.14.0.zip
macOS Binary (x86_64) RNAAgeCalc_1.14.0.tgz
macOS Binary (arm64) RNAAgeCalc_1.14.0.tgz
Source Repository git clone https://git.bioconductor.org/packages/RNAAgeCalc
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/RNAAgeCalc
Bioc Package Browser https://code.bioconductor.org/browse/RNAAgeCalc/
Package Short Url https://bioconductor.org/packages/RNAAgeCalc/
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