Registration Open for Bioc2024
Early registration discount pricing ends May 31!


Candidate Driver Analysis

Bioconductor version: Release (3.19)

Performs both stepwise and backward heuristic search for candidate (epi)genetic drivers based on a binary multi-omics dataset. CaDrA's main objective is to identify features which, together, are significantly skewed or enriched pertaining to a given vector of continuous scores (e.g. sample-specific scores representing a phenotypic readout of interest, such as protein expression, pathway activity, etc.), based on the union occurence (i.e. logical OR) of the events.

Author: Reina Chau [aut, cre] , Katia Bulekova [aut] , Vinay Kartha [aut], Stefano Monti [aut]

Maintainer: Reina Chau <rchau88 at>

Citation (from within R, enter citation("CaDrA")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

How to run CaDrA within a Docker Environment HTML
Permutation-Based Testing HTML R Script
Scoring Functions HTML R Script
Reference Manual PDF


biocViews FeatureExtraction, GeneExpression, Microarray, RNASeq, Software
Version 1.2.0
In Bioconductor since BioC 3.18 (R-4.3) (0.5 years)
License GPL-3 + file LICENSE
Depends R (>= 4.3.0)
Imports doParallel, ggplot2, gplots, graphics, grid, gtable, MASS, methods, misc3d, plyr, ppcor, R.cache, reshape2, stats, SummarizedExperiment
System Requirements
Bug Reports
See More
Suggests BiocManager, devtools, knitr, pheatmap, rmarkdown, testthat (>= 3.1.6)
Linking To
Depends On Me
Imports Me
Suggests Me
Links To Me
Build Report Build Report

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package CaDrA_1.2.0.tar.gz
Windows Binary (64-bit only)
macOS Binary (x86_64) CaDrA_1.2.0.tgz
macOS Binary (arm64) CaDrA_1.2.0.tgz
Source Repository git clone
Source Repository (Developer Access) git clone
Bioc Package Browser
Package Short Url
Package Downloads Report Download Stats