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pathMED

This is the development version of pathMED; to use it, please install the devel version of Bioconductor.

Scoring Personalized Molecular Portraits


Bioconductor version: Development (3.21)

PathMED is a collection of tools to facilitate precision medicine studies with omics data (e.g. transcriptomics). Among its funcionalities, genesets scores for individual samples may be calculated with several methods. These scores may be used to train machine learning models and to predict clinical features on new data. For this, several machine learning methods are evaluated in order to select the best method based on internal validation and to tune the hyperparameters. Performance metrics and a ready-to-use model to predict the outcomes for new patients are returned.

Author: Jordi Martorell-Marugán [cre, aut] ORCID iD ORCID: 0000-0002-5186-0735 , Daniel Toro-Domínguez [aut] ORCID iD ORCID: 0000-0001-8440-312X , Raúl López-Domínguez [aut] ORCID iD ORCID: 0000-0001-8634-117X , Iván Ellson [aut] ORCID iD ORCID: 0000-0001-6307-3141

Maintainer: Jordi Martorell-Marugán <jmartorellm at gmail.com>

Citation (from within R, enter citation("pathMED")):

Installation

To install this package, start R (version "4.5") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

# The following initializes usage of Bioc devel
BiocManager::install(version='devel')

BiocManager::install("pathMED")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("pathMED")
pathMED HTML R Script
Reference Manual PDF
NEWS Text

Details

biocViews Classification, FeatureExtraction, Pathways, Software, Transcriptomics
Version 0.99.2
In Bioconductor since BioC 3.21 (R-4.5)
License GPL-2
Depends R (>= 4.5.0)
Imports BiocParallel, caret, caretEnsemble, decoupleR, ggplot2, GSVA, factoextra, FactoMineR, magrittr, matrixStats, methods, metrica, pbapply, reshape2, singscore, stats, stringi, dplyr
System Requirements
URL https://github.com/jordimartorell/pathMED
Bug Reports https://github.com/jordimartorell/pathMED/issues
See More
Suggests ada, AUCell, Biobase, BiocGenerics, BiocStyle, fgsea(>= 1.15.4), gam, GSEABase, import, kernlab, klaR, knitr, mboost, MLeval, randomForest, ranger, rmarkdown, RUnit, SummarizedExperiment, utils, xgboost
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Package Archives

Follow Installation instructions to use this package in your R session.

Source Package pathMED_0.99.2.tar.gz
Windows Binary (x86_64) pathMED_0.99.2.zip
macOS Binary (x86_64)
macOS Binary (arm64)
Source Repository git clone https://git.bioconductor.org/packages/pathMED
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/pathMED
Bioc Package Browser https://code.bioconductor.org/browse/pathMED/
Package Short Url https://bioconductor.org/packages/pathMED/
Package Downloads Report Download Stats