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SVP

This is the development version of SVP; to use it, please install the devel version of Bioconductor.

Predicting cell states and their variability in single-cell or spatial omics data


Bioconductor version: Development (3.21)

SVP uses the distance between cells and cells, features and features, cells and features in the space of MCA to build nearest neighbor graph, then uses random walk with restart algorithm to calculate the activity score of gene sets (such as cell marker genes, kegg pathway, go ontology, gene modules, transcription factor or miRNA target sets, reactome pathway, ...), which is then further weighted using the hypergeometric test results from the original expression matrix. To detect the spatially or single cell variable gene sets or (other features) and the spatial colocalization between the features accurately, SVP provides some global and local spatial autocorrelation method to identify the spatial variable features. SVP is developed based on SingleCellExperiment class, which can be interoperable with the existing computing ecosystem.

Author: Shuangbin Xu [aut, cre] (ORCID: ), Guangchuang Yu [aut, ctb] (ORCID: )

Maintainer: Shuangbin Xu <xshuangbin at 163.com>

Citation (from within R, enter citation("SVP")):

Installation

To install this package, start R (version "4.5") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

# The following initializes usage of Bioc devel
BiocManager::install(version='devel')

BiocManager::install("SVP")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("SVP")
SVP Vignette HTML R Script
Reference Manual PDF
NEWS Text

Details

biocViews GO, GeneExpression, GeneSetEnrichment, GeneTarget, KEGG, SingleCell, Software, Spatial, Transcription, Transcriptomics
Version 0.99.4
In Bioconductor since BioC 3.21 (R-4.5)
License GPL-3
Depends R (>= 4.1.0)
Imports Rcpp, RcppParallel, methods, cli, dplyr, rlang, S4Vectors, SummarizedExperiment, SingleCellExperiment, SpatialExperiment, BiocGenerics, BiocParallel, fastmatch, pracma, stats, withr, Matrix, DelayedMatrixStats, deldir, utils, BiocNeighbors, ggplot2, ggstar, ggtree, ggfun
System Requirements GNU make
URL https://github.com/YuLab-SMU/SVP
Bug Reports https://github.com/YuLab-SMU/SVP/issues
See More
Suggests rmarkdown, prettydoc, broman, RSpectra, BiasedUrn, knitr, ks, igraph, testthat (>= 3.0.0), scuttle, magrittr, DropletUtils, tibble, tidyr, harmony, aplot, scales, ggsc, scatterpie, scran, scater, STexampleData, ape
Linking To Rcpp, RcppArmadillo (>= 14.0), RcppParallel, RcppEigen, dqrng
Enhances
Depends On Me
Imports Me
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Build Report Build Report

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package SVP_0.99.4.tar.gz
Windows Binary (x86_64) SVP_0.99.4.zip (64-bit only)
macOS Binary (x86_64) SVP_0.99.4.tgz
macOS Binary (arm64) SVP_0.99.4.tgz
Source Repository git clone https://git.bioconductor.org/packages/SVP
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/SVP
Bioc Package Browser https://code.bioconductor.org/browse/SVP/
Package Short Url https://bioconductor.org/packages/SVP/
Package Downloads Report Download Stats