Registration and Call for Abstracts Open for Bioc2024


Meta-analysis for the metagenomic read counts data from different cohorts

Bioconductor version: Release (3.18)

Metagenomic sequencing techniques enable quantitative analyses of the microbiome. However, combining the microbial data from these experiments is challenging due to the variations between experiments. The existing methods for correcting batch effects do not consider the interactions between variables—microbial taxa in microbial studies—and the overdispersion of the microbiome data. Therefore, they are not applicable to microbiome data. We develop a new method, Bayesian Dirichlet-multinomial regression meta-analysis (BDMMA), to simultaneously model the batch effects and detect the microbial taxa associated with phenotypes. BDMMA automatically models the dependence among microbial taxa and is robust to the high dimensionality of the microbiome and their association sparsity.

Author: ZHENWEI DAI <daizwhao at>

Maintainer: ZHENWEI DAI <daizwhao at>

Citation (from within R, enter citation("BDMMAcorrect")):


To install this package, start R (version "4.3") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


Reference Manual PDF


biocViews BatchEffect, Bayesian, ImmunoOncology, Microbiome, Software
Version 1.20.0
In Bioconductor since BioC 3.8 (R-3.5) (5.5 years)
License GPL (>= 2)
Depends R (>= 3.5), vegan, ellipse, ggplot2, ape, SummarizedExperiment
Imports Rcpp (>= 0.12.12), RcppArmadillo, RcppEigen, stats
System Requirements
See More
Suggests knitr, rmarkdown, BiocGenerics
Linking To Rcpp, RcppArmadillo, RcppEigen
Depends On Me
Imports Me
Suggests Me
Links To Me
Build Report Build Report

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package
Windows Binary
macOS Binary (x86_64) BDMMAcorrect_1.20.0.tgz
macOS Binary (arm64) BDMMAcorrect_1.20.0.tgz
Source Repository git clone
Source Repository (Developer Access) git clone
Bioc Package Browser
Package Short Url
Package Downloads Report Download Stats