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CHECK report for GGtools on malbec1

This page was generated on 2019-04-16 11:48:14 -0400 (Tue, 16 Apr 2019).

Package 646/1649HostnameOS / ArchINSTALLBUILDCHECKBUILD BIN
GGtools 5.18.0
VJ Carey
Snapshot Date: 2019-04-15 17:01:12 -0400 (Mon, 15 Apr 2019)
URL: https://git.bioconductor.org/packages/GGtools
Branch: RELEASE_3_8
Last Commit: a112a77
Last Changed Date: 2018-10-30 11:41:43 -0400 (Tue, 30 Oct 2018)
malbec1 Linux (Ubuntu 16.04.6 LTS) / x86_64  OK  OK [ WARNINGS ]UNNEEDED, same version exists in internal repository
merida1 OS X 10.11.6 El Capitan / x86_64  OK  OK  OK  OK UNNEEDED, same version exists in internal repository

Summary

Package: GGtools
Version: 5.18.0
Command: /home/biocbuild/bbs-3.8-bioc/R/bin/R CMD check --install=check:GGtools.install-out.txt --library=/home/biocbuild/bbs-3.8-bioc/R/library --no-vignettes --timings GGtools_5.18.0.tar.gz
StartedAt: 2019-04-16 00:17:32 -0400 (Tue, 16 Apr 2019)
EndedAt: 2019-04-16 00:39:53 -0400 (Tue, 16 Apr 2019)
EllapsedTime: 1340.2 seconds
RetCode: 0
Status:  WARNINGS 
CheckDir: GGtools.Rcheck
Warnings: 1

Command output

##############################################################################
##############################################################################
###
### Running command:
###
###   /home/biocbuild/bbs-3.8-bioc/R/bin/R CMD check --install=check:GGtools.install-out.txt --library=/home/biocbuild/bbs-3.8-bioc/R/library --no-vignettes --timings GGtools_5.18.0.tar.gz
###
##############################################################################
##############################################################################


* using log directory ‘/home/biocbuild/bbs-3.8-bioc/meat/GGtools.Rcheck’
* using R version 3.5.3 (2019-03-11)
* using platform: x86_64-pc-linux-gnu (64-bit)
* using session charset: UTF-8
* using option ‘--no-vignettes’
* checking for file ‘GGtools/DESCRIPTION’ ... OK
* this is package ‘GGtools’ version ‘5.18.0’
* checking package namespace information ... OK
* checking package dependencies ... NOTE
Package which this enhances but not available for checking: ‘MatrixEQTL’
* checking if this is a source package ... OK
* checking if there is a namespace ... OK
* checking for hidden files and directories ... OK
* checking for portable file names ... OK
* checking for sufficient/correct file permissions ... OK
* checking whether package ‘GGtools’ can be installed ... OK
* checking installed package size ... NOTE
  installed size is 72.0Mb
  sub-directories of 1Mb or more:
    R       1.0Mb
    data   27.0Mb
    parts   2.0Mb
    pup     2.0Mb
    rdas   10.3Mb
    vcf    28.8Mb
* checking package directory ... OK
* checking ‘build’ directory ... OK
* checking DESCRIPTION meta-information ... NOTE
Malformed Description field: should contain one or more complete sentences.
* checking top-level files ... OK
* checking for left-over files ... OK
* checking index information ... OK
* checking package subdirectories ... OK
* checking R files for non-ASCII characters ... OK
* checking R files for syntax errors ... OK
* checking whether the package can be loaded ... OK
* checking whether the package can be loaded with stated dependencies ... OK
* checking whether the package can be unloaded cleanly ... OK
* checking whether the namespace can be loaded with stated dependencies ... OK
* checking whether the namespace can be unloaded cleanly ... OK
* checking dependencies in R code ... NOTE
'library' or 'require' call to 'Homo.sapiens' which was already attached by Depends.
  Please remove these calls from your code.
Packages in Depends field not imported from:
  'Homo.sapiens' 'parallel'
  These packages need to be imported from (in the NAMESPACE file)
  for when this namespace is loaded but not attached.
* checking S3 generic/method consistency ... OK
* checking replacement functions ... OK
* checking foreign function calls ... OK
* checking R code for possible problems ... NOTE
plot,gwSnpScreenResult-character: warning in axis(3, at =
  genePosition(x@gene, annlib = x@annotation), col = "red", lwd = 2,
  label = " "): partial argument match of 'label' to 'labels'
.summarize: no visible binding for global variable 'npc'
.summarize: no visible binding for global variable 'maf'
.summarize: no visible binding for global variable 'radiusUsed'
.summarize: no visible binding for global variable 'excl'
.transTab: no visible global function definition for 'snpsBySeqname'
SnpMatrixCisToSummex: no visible global function definition for
  'rowRanges'
add878: no visible binding for global variable 'hmm878'
addcadd: no visible binding for global variable 'bindcadd'
addcadd: no visible global function definition for '%dopar%'
addcadd: no visible global function definition for 'foreach'
addcadd: no visible binding for global variable 'x'
addgwhit: no visible binding for global variable 'gwastagger'
addgwhit: no visible global function definition for 'overlapsAny'
appraise : .redu.fdr: no visible global function definition for
  'setkey'
appraise : .redu.fdr: no visible binding for global variable 'snp'
appraise : .redu.fdr: no visible binding for global variable '.N'
appraise : .redu.fdr : <anonymous>: no visible global function
  definition for 'setkeyv'
appraise : .redu.fdr : <anonymous>: no visible binding for global
  variable '.N'
appraise : .discmods: no visible global function definition for
  '%dopar%'
appraise : .discmods: no visible global function definition for
  'foreach'
buildConfList : z : <anonymous>: no visible binding for global variable
  'pl'
cgff2dt: no visible global function definition for '%dopar%'
cgff2dt: no visible global function definition for 'foreach'
cgff2dt: no visible global function definition for 'as.data.table'
cgff2dt: no visible binding for global variable 'hmm878'
cgff2dt: no visible global function definition for 'overlapsAny'
cgff2dt: no visible binding for global variable 'gwastagger'
cisAssoc: no visible global function definition for 'rowRanges'
cisAssoc: no visible global function definition for 'assays'
cisAssoc: no visible global function definition for 'colData'
cisAssoc: no visible binding for global variable 'chi.squared'
ciseqByCluster : <anonymous>: no visible global function definition for
  'detectCores'
ciseqByCluster: no visible binding for '<<-' assignment to 'firstHalf'
ciseqByCluster: no visible binding for '<<-' assignment to 'secondHalf'
ciseqByCluster: no visible binding for '<<-' assignment to 'firstThird'
ciseqByCluster: no visible binding for '<<-' assignment to 'lastThird'
ciseqByCluster: no visible binding for '<<-' assignment to 'midThird'
ciseqByCluster : setupSplit : <anonymous>: no visible binding for
  global variable 'mclapply'
ciseqByCluster: no visible binding for '<<-' assignment to
  'runOneSplit'
ciseqByCluster : <anonymous>: no visible binding for global variable
  'firstHalf'
ciseqByCluster : <anonymous> : cr2gff: no visible global function
  definition for 'ranges<-'
ciseqByCluster : <anonymous> : cr2gff: no visible global function
  definition for 'export.gff3'
ciseqByCluster: no visible binding for global variable 'firstThird'
ciseqByCluster: no visible binding for global variable 'midThird'
ciseqByCluster: no visible binding for global variable 'lastThird'
ciseqByCluster : <anonymous>: no visible global function definition for
  'runOneSplit'
eqBox: no visible global function definition for 'assay'
eqDesc: no visible global function definition for 'assay'
eqsens_dt: no visible global function definition for 'setnames'
eqsens_dt: no visible global function definition for '%dopar%'
eqsens_dt: no visible global function definition for 'foreach'
eqsens_dt: no visible binding for global variable 'curp'
eqtlTests.me: no visible binding for global variable 'modelLINEAR'
eqtlTests.me: no visible binding for global variable 'SlicedData'
eqtlTests.me: no visible binding for global variable
  'Matrix_eQTL_engine'
eqtlTests.meText: no visible binding for global variable 'modelLINEAR'
eqtlTests.meText: no visible binding for global variable 'SlicedData'
eqtlTests.meText: no visible binding for global variable
  'Matrix_eQTL_engine'
fplot: no visible global function definition for 'forestplot'
genemodel: no visible global function definition for 'select'
genemodel: no visible binding for global variable 'Homo.sapiens'
getAsSlicedData: no visible binding for global variable 'target'
getCisMap: no visible global function definition for 'snpsBySeqname'
get_probechunks: no visible global function definition for 'select'
inflammFilter: no visible binding for global variable 'gwrngs'
inflammFilter: no visible global function definition for 'overlapsAny'
makeSeqinfo: no visible binding for global variable 'hg19.si.df'
plotsens: no visible binding for global variable 'mafs'
plotsens: no visible binding for global variable 'value'
plotsens: no visible binding for global variable 'FDR'
pullHits: no visible global function definition for 'ranges<-'
richNull : <anonymous>: no visible global function definition for
  'bindmaf'
simpleTiling: no visible binding for global variable 'Homo.sapiens'
simpleTiling: no visible global function definition for 'tileGenome'
topKfeats: no visible binding for global variable 'i1'
topKfeats: no visible binding for global variable 'i2'
tscan2df: no visible global function definition for '%dopar%'
tscan2df: no visible global function definition for 'foreach'
tscan2df: no visible binding for global variable 'i'
tscan2gr: no visible global function definition for '%dopar%'
tscan2gr: no visible global function definition for 'foreach'
tscan2gr: no visible binding for global variable 'i'
waldtests : <anonymous>: no visible global function definition for
  'wald.test'
plot,gwSnpScreenResult-character: no visible global function definition
  for 'snpcount'
plot,gwSnpScreenResult-character: no visible global function definition
  for 'snpsBySeqname'
Undefined global functions or variables:
  %dopar% .N FDR Homo.sapiens Matrix_eQTL_engine SlicedData
  as.data.table assay assays bindcadd bindmaf chi.squared colData curp
  detectCores excl export.gff3 firstHalf firstThird foreach forestplot
  gwastagger gwrngs hg19.si.df hmm878 i i1 i2 lastThird maf mafs
  mclapply midThird modelLINEAR npc overlapsAny pl radiusUsed ranges<-
  rowRanges runOneSplit select setkey setkeyv setnames snp snpcount
  snpsBySeqname target tileGenome value wald.test x
* checking Rd files ... OK
* checking Rd metadata ... OK
* checking Rd cross-references ... WARNING
Unknown package ‘MatrixEQTL’ in Rd xrefs
* checking for missing documentation entries ... OK
* checking for code/documentation mismatches ... OK
* checking Rd \usage sections ... OK
* checking Rd contents ... OK
* checking for unstated dependencies in examples ... OK
* checking contents of ‘data’ directory ... OK
* checking data for non-ASCII characters ... OK
* checking data for ASCII and uncompressed saves ... OK
* checking files in ‘vignettes’ ... OK
* checking examples ... OK
Examples with CPU or elapsed time > 5s
            user system elapsed
cisAssoc  58.064  1.736  68.339
eqtlTests 11.964  0.960  59.683
* checking for unstated dependencies in ‘tests’ ... OK
* checking tests ...
  Running ‘cis.R’
  Running ‘eqvgwst.R’
  Running ‘test.meqtlTests.R’
  Running ‘test.meta.trans.R’
  Running ‘testCisMap.R’
  Running ‘testTrans.R’
 OK
* checking for unstated dependencies in vignettes ... OK
* checking package vignettes in ‘inst/doc’ ... OK
* checking running R code from vignettes ... SKIPPED
* checking re-building of vignette outputs ... SKIPPED
* checking PDF version of manual ... OK
* DONE

Status: 1 WARNING, 5 NOTEs
See
  ‘/home/biocbuild/bbs-3.8-bioc/meat/GGtools.Rcheck/00check.log’
for details.



Installation output

GGtools.Rcheck/00install.out

##############################################################################
##############################################################################
###
### Running command:
###
###   /home/biocbuild/bbs-3.8-bioc/R/bin/R CMD INSTALL GGtools
###
##############################################################################
##############################################################################


* installing to library ‘/home/biocbuild/bbs-3.8-bioc/R/library’
* installing *source* package ‘GGtools’ ...
** R
** data
** inst
** byte-compile and prepare package for lazy loading
** help
*** installing help indices
** building package indices
** installing vignettes
** testing if installed package can be loaded
* DONE (GGtools)

Tests output

GGtools.Rcheck/tests/cis.Rout


R version 3.5.3 (2019-03-11) -- "Great Truth"
Copyright (C) 2019 The R Foundation for Statistical Computing
Platform: x86_64-pc-linux-gnu (64-bit)

R is free software and comes with ABSOLUTELY NO WARRANTY.
You are welcome to redistribute it under certain conditions.
Type 'license()' or 'licence()' for distribution details.

R is a collaborative project with many contributors.
Type 'contributors()' for more information and
'citation()' on how to cite R or R packages in publications.

Type 'demo()' for some demos, 'help()' for on-line help, or
'help.start()' for an HTML browser interface to help.
Type 'q()' to quit R.

> 
> suppressPackageStartupMessages(library(GGtools))
> 
> # configure
>    cc = new("CisConfig")
>    chrnames(cc) = "21"
>    genome(cc) = "hg19"
>    nperm(cc) = 2L
>    lkp = try(library(parallel))
>    if (!inherits(lkp, "try-error")) {
+       nc = min(10, detectCores())
+       options(mc.cores=nc)
+       geneApply(cc) = mclapply
+       }
>    estimates(cc) = FALSE
>    set.seed(1234)
> #   system.time(f1 <- cisScores( cc ))
>  #
>  # demonstrate adding annotation on chromatin state and gwas status
>  #
>  eprops = function(ans) {
+  #
+  # only adds fields to values() of the input
+  #
+   data(hmm878)
+   ac = as.character
+   eqr = GRanges(ac(seqnames(ans)), IRanges(ans$snplocs, width=1))
+   fo = findOverlaps(eqr, hmm878)
+   chromcat878 = factor(rep("none", length(ans)), levels=c(unique(hmm878$name), "none"))
+   chromcat878[ queryHits(fo) ] = factor(hmm878$name[subjectHits(fo)])
+   ans$chromcat878 = chromcat878
+  
+   if (require(gwascat)) {
+     data(gwastagger)
+     isgwashit = 1*(overlapsAny(eqr, gwastagger) | ans$snp %in% gwastagger$tagid) # allow match by loc or name
+     ans$isgwashit = isgwashit
+     }
+   ans
+  }
>  extraProps(cc) = eprops
>  set.seed(1234)
>  rhs(cc) = ˜1-1
> if (.Platform$OS.type != "windows") {
+  (f2 <- cisScores( cc ))
+  isTRUE(sum(f2$fdr < 0.05) == 172)  # can change with annotation or location changes, check serialized results if necessary
+ }
get data...build map...

Attaching package: 'Biostrings'

The following object is masked from 'package:base':

    strsplit

NOTE: expanding gene ranges by radius 50000 leads to negative start positions that are reset to 1.
run smFilter...filter probes in map...tests...get data...build map...run smFilter...filter probes in map...tests...get data...build map...run smFilter...filter probes in map...tests...Loading required package: gwascat
gwascat loaded.  Use data(ebicat38) for hg38 coordinates;
 data(ebicat37) for hg19 coordinates.
[1] FALSE
> TRUE
[1] TRUE
> 
> proc.time()
   user  system elapsed 
130.652  15.924 130.657 

GGtools.Rcheck/tests/eqvgwst.Rout


R version 3.5.3 (2019-03-11) -- "Great Truth"
Copyright (C) 2019 The R Foundation for Statistical Computing
Platform: x86_64-pc-linux-gnu (64-bit)

R is free software and comes with ABSOLUTELY NO WARRANTY.
You are welcome to redistribute it under certain conditions.
Type 'license()' or 'licence()' for distribution details.

R is a collaborative project with many contributors.
Type 'contributors()' for more information and
'citation()' on how to cite R or R packages in publications.

Type 'demo()' for some demos, 'help()' for on-line help, or
'help.start()' for an HTML browser interface to help.
Type 'q()' to quit R.

> 
> # april 2011/jan 2012
> # compares gwSnpTests to eqtlTests
> library(GGtools)
Loading required package: GGBase
Loading required package: snpStats
Loading required package: survival
Loading required package: Matrix
Loading required package: data.table
Loading required package: parallel
Loading required package: Homo.sapiens
Loading required package: AnnotationDbi
Loading required package: stats4
Loading required package: BiocGenerics

Attaching package: 'BiocGenerics'

The following objects are masked from 'package:parallel':

    clusterApply, clusterApplyLB, clusterCall, clusterEvalQ,
    clusterExport, clusterMap, parApply, parCapply, parLapply,
    parLapplyLB, parRapply, parSapply, parSapplyLB

The following objects are masked from 'package:Matrix':

    colMeans, colSums, rowMeans, rowSums, which

The following objects are masked from 'package:stats':

    IQR, mad, sd, var, xtabs

The following objects are masked from 'package:base':

    Filter, Find, Map, Position, Reduce, anyDuplicated, append,
    as.data.frame, basename, cbind, colMeans, colSums, colnames,
    dirname, do.call, duplicated, eval, evalq, get, grep, grepl,
    intersect, is.unsorted, lapply, lengths, mapply, match, mget,
    order, paste, pmax, pmax.int, pmin, pmin.int, rank, rbind,
    rowMeans, rowSums, rownames, sapply, setdiff, sort, table, tapply,
    union, unique, unsplit, which, which.max, which.min

Loading required package: Biobase
Welcome to Bioconductor

    Vignettes contain introductory material; view with
    'browseVignettes()'. To cite Bioconductor, see
    'citation("Biobase")', and for packages 'citation("pkgname")'.

Loading required package: IRanges
Loading required package: S4Vectors

Attaching package: 'S4Vectors'

The following objects are masked from 'package:data.table':

    first, second

The following object is masked from 'package:Matrix':

    expand

The following object is masked from 'package:base':

    expand.grid


Attaching package: 'IRanges'

The following object is masked from 'package:data.table':

    shift

Loading required package: OrganismDbi
Loading required package: GenomicFeatures
Loading required package: GenomeInfoDb
Loading required package: GenomicRanges
Loading required package: GO.db

Loading required package: org.Hs.eg.db

Loading required package: TxDb.Hsapiens.UCSC.hg19.knownGene

Attaching package: 'GGtools'

The following object is masked from 'package:stats':

    getCall

> hmceuB36.2021 <- getSS("GGtools", c("20"))
> library(illuminaHumanv1.db)

> cp = get("CPNE1", revmap(illuminaHumanv1SYMBOL))
> hcp = hmceuB36.2021[ probeId(cp), ]
> t1 = gwSnpTests(genesym("CPNE1")˜male, hcp)
> pick = as(t1@.Data[[1]], "data.frame")[22101:22115,]
> rsids = rownames(pick)[!is.na(pick[,1])]
> csq = pick[rsids,1]
> names(csq) = rsids
> fi = tempfile()
> if (file.exists(fi)) unlink(fi, recursive=TRUE)
> t2 = eqtlTests(hcp, ˜male, targdir=fi)
> sco = t2[rsids,][,1]
> unlink(fi, recursive=TRUE)
> comp = (sco-trunc(100*csq,0)/100)/sco
> (!(max(abs(comp)) > .01))
[1] TRUE
> 
> 
> proc.time()
   user  system elapsed 
 26.896   0.912  28.009 

GGtools.Rcheck/tests/test.meqtlTests.Rout


R version 3.5.3 (2019-03-11) -- "Great Truth"
Copyright (C) 2019 The R Foundation for Statistical Computing
Platform: x86_64-pc-linux-gnu (64-bit)

R is free software and comes with ABSOLUTELY NO WARRANTY.
You are welcome to redistribute it under certain conditions.
Type 'license()' or 'licence()' for distribution details.

R is a collaborative project with many contributors.
Type 'contributors()' for more information and
'citation()' on how to cite R or R packages in publications.

Type 'demo()' for some demos, 'help()' for on-line help, or
'help.start()' for an HTML browser interface to help.
Type 'q()' to quit R.

> library(GGtools)
Loading required package: GGBase
Loading required package: snpStats
Loading required package: survival
Loading required package: Matrix
Loading required package: data.table
Loading required package: parallel
Loading required package: Homo.sapiens
Loading required package: AnnotationDbi
Loading required package: stats4
Loading required package: BiocGenerics

Attaching package: 'BiocGenerics'

The following objects are masked from 'package:parallel':

    clusterApply, clusterApplyLB, clusterCall, clusterEvalQ,
    clusterExport, clusterMap, parApply, parCapply, parLapply,
    parLapplyLB, parRapply, parSapply, parSapplyLB

The following objects are masked from 'package:Matrix':

    colMeans, colSums, rowMeans, rowSums, which

The following objects are masked from 'package:stats':

    IQR, mad, sd, var, xtabs

The following objects are masked from 'package:base':

    Filter, Find, Map, Position, Reduce, anyDuplicated, append,
    as.data.frame, basename, cbind, colMeans, colSums, colnames,
    dirname, do.call, duplicated, eval, evalq, get, grep, grepl,
    intersect, is.unsorted, lapply, lengths, mapply, match, mget,
    order, paste, pmax, pmax.int, pmin, pmin.int, rank, rbind,
    rowMeans, rowSums, rownames, sapply, setdiff, sort, table, tapply,
    union, unique, unsplit, which, which.max, which.min

Loading required package: Biobase
Welcome to Bioconductor

    Vignettes contain introductory material; view with
    'browseVignettes()'. To cite Bioconductor, see
    'citation("Biobase")', and for packages 'citation("pkgname")'.

Loading required package: IRanges
Loading required package: S4Vectors

Attaching package: 'S4Vectors'

The following objects are masked from 'package:data.table':

    first, second

The following object is masked from 'package:Matrix':

    expand

The following object is masked from 'package:base':

    expand.grid


Attaching package: 'IRanges'

The following object is masked from 'package:data.table':

    shift

Loading required package: OrganismDbi
Loading required package: GenomicFeatures
Loading required package: GenomeInfoDb
Loading required package: GenomicRanges
Loading required package: GO.db

Loading required package: org.Hs.eg.db

Loading required package: TxDb.Hsapiens.UCSC.hg19.knownGene

Attaching package: 'GGtools'

The following object is masked from 'package:stats':

    getCall

> library(ff)
Loading required package: bit
Attaching package bit
package:bit (c) 2008-2012 Jens Oehlschlaegel (GPL-2)
creators: bit bitwhich
coercion: as.logical as.integer as.bit as.bitwhich which
operator: ! & | xor != ==
querying: print length any all min max range sum summary
bit access: length<- [ [<- [[ [[<-
for more help type ?bit

Attaching package: 'bit'

The following object is masked from 'package:data.table':

    setattr

The following object is masked from 'package:base':

    xor

Attaching package ff
- getOption("fftempdir")=="/tmp/RtmpOGwZgw"

- getOption("ffextension")=="ff"

- getOption("ffdrop")==TRUE

- getOption("fffinonexit")==TRUE

- getOption("ffpagesize")==65536

- getOption("ffcaching")=="mmnoflush"  -- consider "ffeachflush" if your system stalls on large writes

- getOption("ffbatchbytes")==16777216 -- consider a different value for tuning your system

- getOption("ffmaxbytes")==536870912 -- consider a different value for tuning your system


Attaching package: 'ff'

The following objects are masked from 'package:bit':

    clone, clone.default, clone.list

The following objects are masked from 'package:utils':

    write.csv, write.csv2

The following objects are masked from 'package:base':

    is.factor, is.ordered

> 
> tenOn2021 =
+ c( "GI_4557248-S",  "GI_15451784-S", "GI_4557678-S", "GI_9951914-S", "GI_21327679-S",
+  "GI_7669476-I", "GI_7669478-A", "GI_4557290-I", "GI_4557294-A", "GI_41406053-S")
> 
> c22 = getSS("GGdata", "22")
> c22 = c22[probeId(tenOn2021),]
> 
> e1 = eqtlTests(c22, ˜1, targdir = "ooo")
> m1 = meqtlTests(list(c22, c22), list(˜1, ˜1), targdir = "ooobb")
> 
> ae = as.ram(e1@fffile)
opening ff /home/biocbuild/bbs-3.8-bioc/meat/GGtools.Rcheck/tests/ooo/foo_chr22.ff
> am = as.ram(m1@fffile)
> all.equal(as.numeric(ae)*2 ,as.numeric(am) )
[1] TRUE
> 
> 
> proc.time()
   user  system elapsed 
 31.052   1.216  33.429 

GGtools.Rcheck/tests/test.meta.trans.Rout


R version 3.5.3 (2019-03-11) -- "Great Truth"
Copyright (C) 2019 The R Foundation for Statistical Computing
Platform: x86_64-pc-linux-gnu (64-bit)

R is free software and comes with ABSOLUTELY NO WARRANTY.
You are welcome to redistribute it under certain conditions.
Type 'license()' or 'licence()' for distribution details.

R is a collaborative project with many contributors.
Type 'contributors()' for more information and
'citation()' on how to cite R or R packages in publications.

Type 'demo()' for some demos, 'help()' for on-line help, or
'help.start()' for an HTML browser interface to help.
Type 'q()' to quit R.

> 
> heavyTest = function() {
+ library(GGtools)
+ 
+ # verifies that transScores agrees with snp.rhs.tests to obtain best
+ # trans scores
+ 
+ tenOn2021 = 
+ c( "GI_4557248-S",  "GI_15451784-S", "GI_4557678-S", "GI_9951914-S", "GI_21327679-S",
+  "GI_7669476-I", "GI_7669478-A", "GI_4557290-I", "GI_4557294-A", "GI_41406053-S") 
+ 
+ suppressPackageStartupMessages(library(GGtools))
+ 
+ mt1 = meta.transScores(c("GGdata", "GGdata"), rhs=list(˜1, ˜1), snpchr="22", chrnames=as.character(c(20,21)),
+ #
+ # all tests are trans, to verify buffering approach
+ #
+         radius = 2e+06,  K=4, targdir="uiu2",
+     probesToKeep = tenOn2021, batchsize = 200, 
+     geneannopk = "illuminaHumanv1.db", 
+     snpannopk = "SNPlocs.Hsapiens.dbSNP.20111119", gchrpref = "", SMFilterList = list( function(x) x[probeId(tenOn2021),],
+          function(x) x[probeId(tenOn2021), ]),
+     schrpref = "ch", exFilter = list( function(x) x, function(x) x)) 
+ 
+ transTab(mt1)
+ }
> 
> proc.time()
   user  system elapsed 
  0.228   0.024   0.365 

GGtools.Rcheck/tests/testCisMap.Rout


R version 3.5.3 (2019-03-11) -- "Great Truth"
Copyright (C) 2019 The R Foundation for Statistical Computing
Platform: x86_64-pc-linux-gnu (64-bit)

R is free software and comes with ABSOLUTELY NO WARRANTY.
You are welcome to redistribute it under certain conditions.
Type 'license()' or 'licence()' for distribution details.

R is a collaborative project with many contributors.
Type 'contributors()' for more information and
'citation()' on how to cite R or R packages in publications.

Type 'demo()' for some demos, 'help()' for on-line help, or
'help.start()' for an HTML browser interface to help.
Type 'q()' to quit R.

> if (.Platform$OS.type != "windows") {
+ t20 = GGtools:::getCisMap()
+ 
+ NL = GGtools:::namelist(t20)
+ 
+ NL1 = NL[[1]]
+ 
+ t20sl = t20@snplocs[NL1]
+ 
+ probe1 = names(NL)[1]
+ 
+ TARG = t20@generanges[probe1]-50000
+ 
+ d = distance(TARG, t20sl)
+ 
+ all(d <= 50000)
+ } else TRUE

Attaching package: 'BiocGenerics'

The following objects are masked from 'package:parallel':

    clusterApply, clusterApplyLB, clusterCall, clusterEvalQ,
    clusterExport, clusterMap, parApply, parCapply, parLapply,
    parLapplyLB, parRapply, parSapply, parSapplyLB

The following objects are masked from 'package:stats':

    IQR, mad, sd, var, xtabs

The following objects are masked from 'package:base':

    Filter, Find, Map, Position, Reduce, anyDuplicated, append,
    as.data.frame, basename, cbind, colMeans, colSums, colnames,
    dirname, do.call, duplicated, eval, evalq, get, grep, grepl,
    intersect, is.unsorted, lapply, lengths, mapply, match, mget,
    order, paste, pmax, pmax.int, pmin, pmin.int, rank, rbind,
    rowMeans, rowSums, rownames, sapply, setdiff, sort, table, tapply,
    union, unique, unsplit, which, which.max, which.min

Welcome to Bioconductor

    Vignettes contain introductory material; view with
    'browseVignettes()'. To cite Bioconductor, see
    'citation("Biobase")', and for packages 'citation("pkgname")'.


Attaching package: 'S4Vectors'

The following object is masked from 'package:base':

    expand.grid




Attaching package: 'Biostrings'

The following object is masked from 'package:base':

    strsplit

NOTE: expanding gene ranges by radius 50000 leads to negative start positions that are reset to 1.
[1] TRUE
> 
> proc.time()
   user  system elapsed 
 65.448   2.500  73.472 

GGtools.Rcheck/tests/testTrans.Rout


R version 3.5.3 (2019-03-11) -- "Great Truth"
Copyright (C) 2019 The R Foundation for Statistical Computing
Platform: x86_64-pc-linux-gnu (64-bit)

R is free software and comes with ABSOLUTELY NO WARRANTY.
You are welcome to redistribute it under certain conditions.
Type 'license()' or 'licence()' for distribution details.

R is a collaborative project with many contributors.
Type 'contributors()' for more information and
'citation()' on how to cite R or R packages in publications.

Type 'demo()' for some demos, 'help()' for on-line help, or
'help.start()' for an HTML browser interface to help.
Type 'q()' to quit R.

> # verifies that transScores agrees with snp.rhs.tests to obtain best
> # trans scores
> 
> suppressPackageStartupMessages(library(GGtools))
> 
> tenOn2021 = 
+ c( "GI_4557248-S",  "GI_15451784-S", "GI_4557678-S", "GI_9951914-S", "GI_21327679-S",
+  "GI_7669476-I", "GI_7669478-A", "GI_4557290-I", "GI_4557294-A", "GI_41406053-S") 
> 
> tconf = new("TransConfig")
> radius(tconf) = 2000000L
> smpack(tconf) = "GGdata"
> rhs(tconf) = ˜1
> snpchr(tconf) = "22"  # we get scores for all SNP on this chrom
> chrnames(tconf) = c("20", "21")
> gbufsize(tconf) = 4L
> smFilter(tconf) = function(x) x[probeId(tenOn2021),]
> snpannopk(tconf) = snplocsDefault()
> schrpref(tconf) = "ch"
> exFilter(tconf) = function(x)x
> gchrpref = ""
> batchsize(tconf) = 200L
> 
> suppressPackageStartupMessages(library(GGtools))
> 
> t1 = transScores(tconf)
Loading required package: illuminaHumanv1.db

opening ff /home/biocbuild/bbs-3.8-bioc/meat/GGtools.Rcheck/tests/cisScratch22/tsc_20_chr22.ff
2opening ff /home/biocbuild/bbs-3.8-bioc/meat/GGtools.Rcheck/tests/cisScratch22/tsctmp2_chr22.ff
> 
> #"GGdata", rhs=˜1, snpchr="22", chrnames=as.character(c(20,21)),
> #
> # all tests are trans, to verify buffering approach
> #
> #        radius = 2e+06,  K=4,
> #    probesToKeep = tenOn2021, batchsize = 200, 
> #    geneannopk = "illuminaHumanv1.db", 
> #    snpannopk = "SNPlocs.Hsapiens.dbSNP.20111119", gchrpref = "", 
> #    schrpref = "ch", exFilter = function(x) x) 
> 
> if (.Platform$OS.type != "windows") {
+   tt1 = transTab(t1)
+   
+   cleanup_transff = function(x) {
+    fn = attr(attr(x@base$scores, "physical"), "filename")
+    comps = strsplit(fn, "/")[[1]]
+    nel = length(comps)
+    unlink(comps[nel-1], recursive=TRUE)
+   }
+   
+   cleanup_transff(t1)
+   
+   c22 = getSS("GGdata", "22")
+   
+   exl = lapply(tenOn2021, function(x) exprs(c22)[x,])
+   rhst = lapply(1:length(exl), function(g) {
+        ex = exl[[g]]
+        snp.rhs.tests(ex˜1, snp.data=smList(c22)[[1]], fam="gaussian", uncertain=TRUE) })
+   csnp1 = sapply(rhst, function(x)chi.squared(x)[1])
+   csnp50 = sapply(rhst, function(x)chi.squared(x)[50])
+   
+   
+   #all(abs(floor(sort(csnp1, decreasing=TRUE)[1:4]*10)/10 - tt1[1:4,2]) < .01)
+   #all(abs(floor(sort(csnp50, decreasing=TRUE)[1:4]*10)/10 - tt1[197:200,2]) < 0.01)
+   
+   ttdt = data.table(tt1)
+   SS = sort(sapply(rhst, function(x) max(chi.squared(x), na.rm=TRUE))) 
+   TT = sort(ttdt[,max(chisq),by="probeid"]$V1) 
+   maxchk = (max(abs(SS-TT))<.01)
+   
+   # needs more work, tt1 is organized by snp
+   #SS = sort(sapply(rhst, function(x) min(chi.squared(x), na.rm=TRUE))) 
+   #TT = sort(ttdt[,min(chisq),by="probeid"]$V1) 
+   #minchk = (max(abs(SS-TT))<.01)
+   
+   maxchk 
+ }
Loading required package: SNPlocs.Hsapiens.dbSNP144.GRCh37
Loading required package: BSgenome
Loading required package: Biostrings
Loading required package: XVector

Attaching package: 'Biostrings'

The following object is masked from 'package:base':

    strsplit

Loading required package: rtracklayer
[1] TRUE
>   
> 
> proc.time()
   user  system elapsed 
136.076   3.556 162.325 

Example timings

GGtools.Rcheck/GGtools-Ex.timings

nameusersystemelapsed
All.cis0.0040.0000.000
CisConfig-class0.0000.0000.002
EqAppr-class000
GGtools-package000
TransConfig-class0.0000.0000.001
b10.0760.0000.076
best.cis.eQTLs0.0000.0000.001
best.trans.eQTLs0.0000.0000.001
bindmaf000
cgff2dt0.0120.0000.014
cisAssoc58.064 1.73668.339
cisRun-class0.0000.0000.001
ciseqByCluster000
collectBest0.0000.0000.001
concatCis0.0000.0000.001
eqBox3.0800.0883.177
eqsens_dt000
eqtlTests11.964 0.96059.683
eqtlTests.me0.0000.0000.001
eqtlTestsManager-class0.0000.0000.001
ex3.0240.0443.082
getCisMap000
gwSnpTests3.8400.2404.204
hmm8780.8440.0200.868
pifdr0.9840.0681.054
qqhex0.1280.0040.132
sampsInVCF0.0960.0000.108
sensiCisInput-class0.0000.0000.001
sensiCisOutput-class0.0000.0000.001
simpleTiling000
snplocsDefault000
strMultPop0.1040.0080.112
transManager-class000
transScores000
vcf2sm0.1160.0040.140