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Analysis of pooled genetic screens

Bioconductor version: Release (3.18)

Package for the analysis of pooled genetic screens (e.g. CRISPR-KO). The analysis of such screens is based on the comparison of gRNA abundances before and after a cell proliferation phase. The gscreend packages takes gRNA counts as input and allows detection of genes whose knockout decreases or increases cell proliferation.

Author: Katharina Imkeller [cre, aut], Wolfgang Huber [aut]

Maintainer: Katharina Imkeller <k.imkeller at dkfz.de>

Citation (from within R, enter citation("gscreend")):


To install this package, start R (version "4.3") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


Reference Manual PDF


biocViews CRISPR, PooledScreens, Software, StatisticalMethod
Version 1.16.0
In Bioconductor since BioC 3.10 (R-3.6) (4.5 years)
License GPL-3
Depends R (>= 3.6)
Imports SummarizedExperiment, nloptr, fGarch, methods, BiocParallel, graphics
System Requirements
URL https://github.com/imkeller/gscreend
Bug Reports https://github.com/imkeller/gscreend/issues
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Follow Installation instructions to use this package in your R session.

Source Package
Windows Binary gscreend_1.16.0.zip
macOS Binary (x86_64) gscreend_1.16.0.tgz
macOS Binary (arm64) gscreend_1.16.0.tgz
Source Repository git clone https://git.bioconductor.org/packages/gscreend
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/gscreend
Bioc Package Browser https://code.bioconductor.org/browse/gscreend/
Package Short Url https://bioconductor.org/packages/gscreend/
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