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Computes estimates of the probability of related individuals sharing a rare variant

Bioconductor version: Release (3.19)

Rare Variant Sharing (RVS) implements tests of association and linkage between rare genetic variant genotypes and a dichotomous phenotype, e.g. a disease status, in family samples. The tests are based on probabilities of rare variant sharing by relatives under the null hypothesis of absence of linkage and association between the rare variants and the phenotype and apply to single variants or multiple variants in a region (e.g. gene-based test).

Author: Alexandre Bureau, Ingo Ruczinski, Samuel Younkin, Thomas Sherman

Maintainer: Alexandre Bureau <alexandre.bureau at>

Citation (from within R, enter citation("RVS")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

The RVS Package HTML R Script
Reference Manual PDF


biocViews ExomeSeq, Genetics, GenomeWideAssociation, ImmunoOncology, Software, VariantDetection, WholeGenome
Version 1.26.0
In Bioconductor since BioC 3.6 (R-3.4) (6.5 years)
License GPL-2
Depends R (>= 3.5.0)
Imports GENLIB, gRain, snpStats, kinship2, methods, stats, utils, R.utils
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Suggests knitr, testthat, rmarkdown, BiocStyle, VariantAnnotation
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Follow Installation instructions to use this package in your R session.

Source Package RVS_1.26.0.tar.gz
Windows Binary
macOS Binary (x86_64) RVS_1.26.0.tgz
macOS Binary (arm64) RVS_1.26.0.tgz
Source Repository git clone
Source Repository (Developer Access) git clone
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