library(maftools)
#path to TCGA LAML MAF file
laml.maf = system.file('extdata', 'tcga_laml.maf.gz', package = 'maftools')
#clinical information containing survival information and histology. This is optional
laml.clin = system.file('extdata', 'tcga_laml_annot.tsv', package = 'maftools')

laml = read.maf(maf = laml.maf,
                clinicalData = laml.clin,
                verbose = FALSE)

0.1 Including Transition/Transversions into oncoplot

#By default the function plots top20 mutated genes
oncoplot(maf = laml, draw_titv = TRUE)