Changes in version 2.22.0 o Regular maintenance, stable release. Changes in version 2.20.0 o Regular maintenance, stable release. Changes in version 2.18.0 o Regular maintenance, stable release. Changes in version 2.16.0 o Regular maintenance, stable release. Changes in version 2.14.0 o Regular maintenance, stable release. Changes in version 2.12.0 o Regular maintenance, stable release. Changes in version 2.10.0 o Regular maintenance, stable release. Changes in version 2.8.0 o Regular maintenance, stable release. Changes in version 2.6.0 o Make available GSEA-2T and aREA-3T algorithms for single-sample analysis. Changes in version 2.4.0 o Improved RTN workflows. Changes in version 2.2.0 o Improved annotation slots for TNA/TNI classes. Changes in version 1.14.0 o Concluded the VSE/EVSE pipeline, including examples. o Improved computational performance and RTN workflows. o In order to improve stability and portability, all dependencies have been extensively revised and, when available, replaced with more stable options. o In order to simplify documentation and usability, some pipelines have been revised and should be distributed as separated packages, or 'on demand', focused on the main workflow, as for example the new 'RTNduals' package. Changes in version 1.12.0 o Improved computational performance and RTN workflows. o Introduced partial correlation metric to derive regulons. Changes in version 1.10.0 o Improved computational performance and RTN workflows. Changes in version 1.8.0 o Improved computational performance and RTN workflows. Changes in version 1.6.0 o Improved computational performance for permutation analysis and other parallel processing pipelines. o Fix a phyper function issue. Changes in version 1.4.0 o Introduced 2-tailed GSEA and other related methods. Changes in version 1.2.0 o Introduced variant set enrichment analysis for regulons. Changes in version 1.0.0 o 1st Bioconductor release of RTN [2013-10-15].