BioNet-package {BioNet} | R Documentation |
This package provides functions for the integrated analysis of biological networks and the detection of functional modules. Different datasets can be integrated into the network by assigning p-values derived from statistical tests to the nodes of the network. E.g. p-values obtained from the differential expression of genes from an Affymetrix array are assigned to the nodes of an protein-protein interaction network. By fitting a beta-uniform mixture model and calculating scores from the p-values, overall scores of network regions can be calculated and an integer linear programming algorithm identifies the maximum scoring subnetwork.
Package: | BioNet |
Type: | Package |
Version: | 1.29.1 |
Date: | 2015-09-11 |
License: | GPL (>=2) |
LazyLoad: | yes |
Marcus Dittrich, Daniela Beisser
Maintainer: Marcus Dittrich <marcus.dittrich@biozentrum.uni-wuerzburg.de>
M. T. Dittrich, G. W. Klau, A. Rosenwald, T. Dandekar and T. Mueller (2008) Identifying functional modules in protein-protein interaction networks: an integrated exact approach. (ISMB2008) Bioinformatics 24: 13. i223-i231 Jul.
D. Beisser, G. W. Klau, T. Dandekar, T. Mueller and M. Dittrich (2010) BioNet: an R-package for the Functional Analysis of Biological Networks. Bioinformatics 26:08. 1129-1130 Apr.