DOI: 10.18129/B9.bioc.pathwayPCA  

This package is for version 3.16 of Bioconductor; for the stable, up-to-date release version, see pathwayPCA.

Integrative Pathway Analysis with Modern PCA Methodology and Gene Selection

Bioconductor version: 3.16

pathwayPCA is an integrative analysis tool that implements the principal component analysis (PCA) based pathway analysis approaches described in Chen et al. (2008), Chen et al. (2010), and Chen (2011). pathwayPCA allows users to: (1) Test pathway association with binary, continuous, or survival phenotypes. (2) Extract relevant genes in the pathways using the SuperPCA and AES-PCA approaches. (3) Compute principal components (PCs) based on the selected genes. These estimated latent variables represent pathway activities for individual subjects, which can then be used to perform integrative pathway analysis, such as multi-omics analysis. (4) Extract relevant genes that drive pathway significance as well as data corresponding to these relevant genes for additional in-depth analysis. (5) Perform analyses with enhanced computational efficiency with parallel computing and enhanced data safety with S4-class data objects. (6) Analyze studies with complex experimental designs, with multiple covariates, and with interaction effects, e.g., testing whether pathway association with clinical phenotype is different between male and female subjects. Citations: Chen et al. (2008) ; Chen et al. (2010) ; and Chen (2011) .

Author: Gabriel Odom [aut, cre], James Ban [aut], Lizhong Liu [aut], Lily Wang [aut], Steven Chen [aut]

Maintainer: Gabriel Odom <gabriel.odom at>

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HTML R Script Integrative Pathway Analysis with pathwayPCA
HTML R Script Suppl. 1. Quickstart Guide
HTML R Script Suppl. 2. Importing Data
HTML R Script Suppl. 3. Create Data Objects
HTML R Script Suppl. 4. Test Pathway Significance
HTML R Script Suppl. 5. Visualizing the Results
PDF   Reference Manual
Text   NEWS


biocViews CellBiology, Classification, CopyNumberVariation, DNAMethylation, DimensionReduction, Epigenetics, FeatureExtraction, FunctionalGenomics, GeneExpression, GenePrediction, GeneSetEnrichment, GeneSignaling, GeneTarget, Genetics, GenomeWideAssociation, GenomicVariation, Lipidomics, Metabolomics, MultipleComparison, Pathways, PrincipalComponent, Proteomics, Regression, SNP, Software, Survival, SystemsBiology, Transcription, Transcriptomics
Version 1.14.0
In Bioconductor since BioC 3.9 (R-3.6) (4 years)
License GPL-3
Depends R (>= 3.1)
Imports lars, methods, parallel, stats, survival, utils
Suggests airway, circlize, grDevices, knitr, RCurl, reshape2, rmarkdown, SummarizedExperiment, survminer, testthat, tidyverse
Depends On Me
Imports Me fcoex
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