DOI: 10.18129/B9.bioc.methylSig  

This package is for version 3.16 of Bioconductor; for the stable, up-to-date release version, see methylSig.

MethylSig: Differential Methylation Testing for WGBS and RRBS Data

Bioconductor version: 3.16

MethylSig is a package for testing for differentially methylated cytosines (DMCs) or regions (DMRs) in whole-genome bisulfite sequencing (WGBS) or reduced representation bisulfite sequencing (RRBS) experiments. MethylSig uses a beta binomial model to test for significant differences between groups of samples. Several options exist for either site-specific or sliding window tests, and variance estimation.

Author: Yongseok Park [aut], Raymond G. Cavalcante [aut, cre]

Maintainer: Raymond G. Cavalcante <rcavalca at>

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biocViews DNAMethylation, DifferentialMethylation, Epigenetics, MethylSeq, Regression, Software
Version 1.10.0
In Bioconductor since BioC 3.11 (R-4.0) (3 years)
License GPL-3
Depends R (>= 3.6)
Imports bsseq, DelayedArray, DelayedMatrixStats, DSS, IRanges, GenomeInfoDb, GenomicRanges, methods, parallel, stats, S4Vectors
Suggests BiocStyle, bsseqData, knitr, rmarkdown, testthat (>= 2.1.0), covr
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