DOI: 10.18129/B9.bioc.ISLET  

This package is for version 3.16 of Bioconductor; for the stable, up-to-date release version, see ISLET.

Individual-Specific ceLl typE referencing Tool

Bioconductor version: 3.16

ISLET is a method to conduct signal deconvolution for general -omics data. It can estimate the individual-specific and cell-type-specific reference panels, when there are multiple samples observed from each subject. It takes the input of the observed mixture data (feature by sample matrix), and the cell type mixture proportions (sample by cell type matrix), and the sample-to-subject information. It can solve for the reference panel on the individual-basis. It can also conduct test to identify cell-type-specific differential expression (csDE) genes.

Author: Hao Feng [aut, cre], Qian Li [aut]

Maintainer: Hao Feng <hxf155 at>

Citation (from within R, enter citation("ISLET")):


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biocViews DifferentialExpression, DifferentialMethylation, GeneExpression, RNASeq, Sequencing, Software, Transcription, Transcriptomics
Version 1.0.0
In Bioconductor since BioC 3.16 (R-4.2) (< 6 months)
License GPL-2
Depends R (>= 4.1.0), Matrix, parallel, BiocParallel, SummarizedExperiment, BiocGenerics
Imports stats, methods
Suggests BiocStyle, knitr, rmarkdown, htmltools, RUnit
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