normr

DOI: 10.18129/B9.bioc.normr    

Normalization and difference calling in ChIP-seq data

Bioconductor version: Release (3.15)

Robust normalization and difference calling procedures for ChIP-seq and alike data. Read counts are modeled jointly as a binomial mixture model with a user-specified number of components. A fitted background estimate accounts for the effect of enrichment in certain regions and, therefore, represents an appropriate null hypothesis. This robust background is used to identify significantly enriched or depleted regions.

Author: Johannes Helmuth [aut, cre], Ho-Ryun Chung [aut]

Maintainer: Johannes Helmuth <johannes.helmuth at laborberlin.com>

Citation (from within R, enter citation("normr")):

Installation

To install this package, start R (version "4.2") and enter:

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("normr")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("normr")

 

HTML R Script Introduction to the normR package
PDF   Reference Manual
Text   NEWS

Details

biocViews Alignment, Bayesian, ChIPSeq, Classification, DataImport, DifferentialPeakCalling, FunctionalGenomics, Genetics, MultipleComparison, Normalization, PeakDetection, Preprocessing, RIPSeq, Software
Version 1.22.0
In Bioconductor since BioC 3.4 (R-3.3) (6 years)
License GPL-2
Depends R (>= 3.3.0)
Imports methods, stats, utils, grDevices, parallel, GenomeInfoDb, GenomicRanges, IRanges, Rcpp (>= 0.11), qvalue(>= 2.2), bamsignals(>= 1.4), rtracklayer(>= 1.32)
LinkingTo Rcpp
Suggests BiocStyle, testthat (>= 1.0), knitr, rmarkdown
SystemRequirements C++11
Enhances BiocParallel
URL https://github.com/your-highness/normR
BugReports https://github.com/your-highness/normR/issues
Depends On Me
Imports Me
Suggests Me
Links To Me
Build Report  

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package normr_1.22.0.tar.gz
Windows Binary normr_1.22.0.zip
macOS Binary (x86_64) normr_1.22.0.tgz
Source Repository git clone https://git.bioconductor.org/packages/normr
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/normr
Package Short Url https://bioconductor.org/packages/normr/
Package Downloads Report Download Stats

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