Changes in version 1.9.3 (2021-12-16) - Add lincs2020.h5 database Changes in version 1.9.2 (2021-12-06) - Add dest_path parameter to getCmapCEL function Changes in version 1.2.1 (2020-08-14) - Edited vignette containing 'DEGs and Cutoffs Definition' subsections to document how to defining query DEGs and gene set reference database by setting LFC scores and FDR cutoffs. Changes in version 1.1.0 (2019-10-23) - Initial version Changes in version 0.99.10 (2019-10-22) - Stored data in ExperimentHub - Saved LINCS gctx file to hdf5 file in batches - Saved cmap databases (cmap, cmap_rank, cmap_expr) to hdf5 files - Loaded hdf5 file into R as SummarizedExperiment object - hdf5 file includes matrix, rownames and colnames Changes in version 0.99.0 (2019-04-02) - Needed 50Gb memory to load matrix in LINCS gctx file and save as HDF5 backed SE object