synlet

DOI: 10.18129/B9.bioc.synlet    

Hits Selection for Synthetic Lethal RNAi Screen Data

Bioconductor version: Release (3.14)

Select hits from synthetic lethal RNAi screen data. For example, there are two identical celllines except one gene is knocked-down in one cellline. The interest is to find genes that lead to stronger lethal effect when they are knocked-down further by siRNA. Quality control and various visualisation tools are implemented. Four different algorithms could be used to pick up the interesting hits. This package is designed based on 384 wells plates, but may apply to other platforms with proper configuration.

Author: Chunxuan Shao <c.shao at dkfz-heidelberg.de>

Maintainer: Chunxuan Shao <c.shao at dkfz-heidelberg.de>

Citation (from within R, enter citation("synlet")):

Installation

To install this package, start R (version "4.1") and enter:

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("synlet")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("synlet")

 

HTML R Script A working Demo for synlet
PDF   Reference Manual
Text   NEWS

Details

biocViews CellBasedAssays, FeatureExtraction, ImmunoOncology, Preprocessing, QualityControl, Software, Visualization
Version 1.24.0
In Bioconductor since BioC 3.2 (R-3.2) (6.5 years)
License GPL-3
Depends R (>= 3.2.0), ggplot2
Imports doBy, dplyr, grid, magrittr, RColorBrewer, RankProd, reshape2
LinkingTo
Suggests knitr, testthat, rmarkdown
SystemRequirements
Enhances
URL
Depends On Me
Imports Me
Suggests Me
Links To Me
Build Report  

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package synlet_1.24.0.tar.gz
Windows Binary synlet_1.24.0.zip
macOS 10.13 (High Sierra) synlet_1.24.0.tgz
Source Repository git clone https://git.bioconductor.org/packages/synlet
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/synlet
Package Short Url https://bioconductor.org/packages/synlet/
Package Downloads Report Download Stats
Old Source Packages for BioC 3.14 Source Archive

Documentation »

Bioconductor

R / CRAN packages and documentation

Support »

Please read the posting guide. Post questions about Bioconductor to one of the following locations: