SIAMCAT

DOI: 10.18129/B9.bioc.SIAMCAT    

Statistical Inference of Associations between Microbial Communities And host phenoTypes

Bioconductor version: Release (3.13)

Pipeline for Statistical Inference of Associations between Microbial Communities And host phenoTypes (SIAMCAT). A primary goal of analyzing microbiome data is to determine changes in community composition that are associated with environmental factors. In particular, linking human microbiome composition to host phenotypes such as diseases has become an area of intense research. For this, robust statistical modeling and biomarker extraction toolkits are crucially needed. SIAMCAT provides a full pipeline supporting data preprocessing, statistical association testing, statistical modeling (LASSO logistic regression) including tools for evaluation and interpretation of these models (such as cross validation, parameter selection, ROC analysis and diagnostic model plots).

Author: Konrad Zych [aut] , Jakob Wirbel [aut, cre] , Georg Zeller [aut] , Morgan Essex [ctb], Nicolai Karcher [ctb], Kersten Breuer [ctb]

Maintainer: Jakob Wirbel <jakob.wirbel at embl.de>

Citation (from within R, enter citation("SIAMCAT")):

Installation

To install this package, start R (version "4.1") and enter:

if (!requireNamespace("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("SIAMCAT")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("SIAMCAT")

 

HTML R Script SIAMCAT basic vignette
HTML R Script SIAMCAT confounder example
HTML R Script SIAMCAT holdout testing
HTML R Script SIAMCAT input
HTML R Script SIAMCAT meta-analysis
HTML R Script SIAMCAT ML pitfalls
PDF   Reference Manual
Text   NEWS

Details

biocViews Classification, Clustering, FeatureExtraction, GeneticVariability, ImmunoOncology, Metagenomics, Microbiome, MultipleComparison, Preprocessing, Regression, Sequencing, Software
Version 1.12.0
In Bioconductor since BioC 3.7 (R-3.5) (3.5 years)
License GPL-3
Depends R (>= 3.6.0), mlr, phyloseq
Imports beanplot, glmnet, graphics, grDevices, grid, gridBase, gridExtra, LiblineaR, matrixStats, methods, ParamHelpers, pROC, PRROC, RColorBrewer, scales, stats, stringr, utils, infotheo, progress, corrplot
LinkingTo
Suggests BiocStyle, optparse, testthat, knitr, rmarkdown, tidyverse, ggpubr
SystemRequirements
Enhances
URL
Depends On Me
Imports Me
Suggests Me
Links To Me
Build Report  

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package SIAMCAT_1.12.0.tar.gz
Windows Binary SIAMCAT_1.12.0.zip
macOS 10.13 (High Sierra) SIAMCAT_1.12.0.tgz
Source Repository git clone https://git.bioconductor.org/packages/SIAMCAT
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/SIAMCAT
Package Short Url https://bioconductor.org/packages/SIAMCAT/
Package Downloads Report Download Stats

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