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Quantitative DNA sequencing for chromosomal aberrations

Bioconductor version: 3.0

Quantitative DNA sequencing for chromosomal aberrations. The genome is divided into non-overlapping fixed-sized bins, number of sequence reads in each counted, adjusted with a simultaneous two-dimensional loess correction for sequence mappability and GC content, and filtered to remove spurious regions in the genome. Downstream steps of segmentation and calling are also implemented via packages DNAcopy and CGHcall, respectively.

Author: Ilari Scheinin [aut], Daoud Sie [aut, cre], Henrik Bengtsson [aut]

Maintainer: Daoud Sie <d.sie at>

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PDF R Script Introduction to QDNAseq
PDF   Reference Manual
Text   NEWS


biocViews CopyNumberVariation, DNASeq, Genetics, GenomeAnnotation, Preprocessing, QualityControl, Sequencing, Software
Version 1.2.4
In Bioconductor since BioC 2.14 (R-3.1)
License GPL
Depends R (>= 2.15.0)
Imports graphics, methods, stats, utils, matrixStats (>= 0.9.4), R.utils (>= 1.28.4), Biobase(>= 2.18.0), CGHbase(>= 1.18.0), CGHcall(>= 2.18.0), DNAcopy(>= 1.32.0), Rsamtools(>= 1.10.0)
Suggests R.cache (>= 0.9.0), digest, snowfall, BSgenome, GenomeInfoDb
Depends On Me
Imports Me
Suggests Me
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