##############################################################################
##############################################################################
###
### Running command:
###
###   /Library/Frameworks/R.framework/Resources/bin/R CMD build --keep-empty-dirs --no-resave-data metaseqR2
###
##############################################################################
##############################################################################


* checking for file ‘metaseqR2/DESCRIPTION’ ... OK
* preparing ‘metaseqR2’:
* checking DESCRIPTION meta-information ... OK
* cleaning src
* installing the package to build vignettes
* creating vignettes ... ERROR
--- re-building ‘metaseqr2-annotation.Rmd’ using rmarkdown
Failed with error:  'unable to load shared object '/Library/Frameworks/R.framework/Versions/4.4-x86_64/Resources/library/RMySQL/libs/RMySQL.so':
  dlopen(/Library/Frameworks/R.framework/Versions/4.4-x86_64/Resources/library/RMySQL/libs/RMySQL.so, 0x0006): Library not loaded: '@loader_path/../../../../opt/openssl@3/lib/libssl.3.dylib'
  Referenced from: '/usr/local/Cellar/mysql/8.1.0/lib/libmysqlclient.22.dylib'
  Reason: tried: '/usr/local/Cellar/mysql/8.1.0/lib/../../../../opt/openssl@3/lib/libssl.3.dylib' (no such file), '/Library/Frameworks/R.framework/Resources/lib/libssl.3.dylib' (no such file), '/usr/local/jdk-21.jdk/Contents/Home/lib/server/libssl.3.dylib' (no such file)'

Quitting from lines 132-153 [example-2] (metaseqr2-annotation.Rmd)
Error: processing vignette 'metaseqr2-annotation.Rmd' failed with diagnostics:
cannot open URL 'http://hgdownload.soe.ucsc.edu/goldenPath/mm10/database/ensemblSource.txt.gz'
--- failed re-building ‘metaseqr2-annotation.Rmd’

--- re-building ‘metaseqr2-statistics.Rmd’ using rmarkdown
Warning: call dbDisconnect() when finished working with a connection
2024-03-01 20:26:19.404 R[81977:911573776] XType: com.apple.fonts is not accessible.
2024-03-01 20:26:19.409 R[81977:911573776] XType: XTFontStaticRegistry is enabled.
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statEdger              package:metaseqR2               R Documentation

_S_t_a_t_i_s_t_i_c_a_l _t_e_s_t_i_n_g _w_i_t_h _e_d_g_e_R

_D_e_s_c_r_i_p_t_i_o_n:

     This function is a wrapper over edgeR statistical testing. It
     accepts a matrix of normalized gene counts or an S4 object
     specific to each normalization algorithm supported by metaseqR2.

_U_s_a_g_e:

         statEdger(object, sampleList, contrastList = NULL,
             statArgs = NULL)
     
_A_r_g_u_m_e_n_t_s:

  object: a matrix or an object specific to each normalization
          algorithm supported by metaseqR2, containing normalized
          counts. See also Details.

sampleList: the list containing condition names and the samples under
          each condition.

contrastList: vector of contrasts as defined in the main help page of
          'metaseqr2'. See also Details.

statArgs: a list of edgeR statistical algorithm parameters. See the
          result of 'getDefaults("statistics",' '"edger")' for an
          example and how you can modify it.

_D_e_t_a_i_l_s:

     Regarding 'object', apart from 'matrix' (also for NOISeq), the
     object can be a 'SeqExpressionSet' (EDASeq), 'CountDataSet'
     (DESeq), 'DGEList' (edgeR), 'DESeqDataSet' (DESeq2), 'SeqCountSet'
     (DSS) or 'ABSDataSet' (ABSSeq).

     Regarding 'contrastList' it can also be a named structured list of
     contrasts as returned by the internal function
     'metaseqR2:::makeContrastList'.

_V_a_l_u_e:

     A named list of p-values, whose names are the names of the
     contrasts.

_A_u_t_h_o_r(_s):

     Panagiotis Moulos

_E_x_a_m_p_l_e_s:

     require(edgeR)
     dataMatrix <- metaseqR2:::exampleCountData(2000)
     sampleList <- list(A=c("A1","A2"),B=c("B1","B2","B3"))
     contrast <- "A_vs_B"
     normDataMatrix <- normalizeEdger(dataMatrix,sampleList)
     p <- statEdger(normDataMatrix,sampleList,contrast)
     

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